Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- arthralgia
- weakness
- vasculitis
- lower-extremity vascular purpura
Outros fatores diagnósticos
- peripheral neuropathy
- sicca symptoms
- hypertension
- Raynaud phenomenon
- lower extremity skin ulcers
- diplopia
- ataxia
- headache
- confusion
- retinal hemorrhage/retinal vein thrombosis
- acrocyanosis
Fatores de risco
- hepatitis C virus (HCV) infection
- other viral infections
- autoimmune disorders
- lymphoproliferative disorders
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- fasting qualitative serum cryoglobulins
- CBC
- comprehensive chemistry panel
- erythrocyte sedimentation rate, CRP
- urinalysis
- ECG
- CXR
- rheumatoid factor
- complement CH50, C3, C4
- hepatitis C virus (HCV) antibody
- hepatitis B virus antibody
Investigações a serem consideradas
- HIV antibody
- antinuclear antibody (ANA), Sjogren syndrome antigens, extractable nuclear antigen (ENA) antibody
- skin biopsy
Algoritmo de tratamento
mixed cryoglobulinemia
malignancy-associated cryoglobulinemia (type I)
Colaboradores
Autores
Gurjit S. Kaeley, MBBS, MRCP
Professor of Medicine
Chief, Division of Rheumatology and Clinical Immunology
Medical Director, Musculoskeletal Ultrasound Program
Program Director, Rheumatology Fellowship
University of Florida College of Medicine - Jacksonville
Jacksonville
FL
გაფრთხილება:
GSK declares that he has no competing interests.
რეცენზენტები
Morie Gertz, MD
Professor of Medicine
Division of Hematology
Mayo Clinic
Rochester
MN
გაფრთხილება:
MG is an author of a number of references cited in this topic.
Antonio Palumbo, MD
Associate Professor
University of Turin
Chief
Myeloma Unit
Ospedale Molinette
Turin
Italy
გაფრთხილება:
AP declares that he has no competing interests.
Xavier Leleu, MD, PhD
Instructor in Hematology
Department of Hematology
Hopital Huriez CHRU
Lille
France
გაფრთხილება:
XL has received lecture fees and research funding from Janssen-Cilag, Celgene, Chugai, Amgen, Novartis, Mundipharma, and Roche. XL is an author of a number of references cited in this topic.
Rajan Madhok, MD, FCRP
Consultant Physician and Rheumatologist
Centre for Rheumatic Diseases
Glasgow Royal Infirmary
Glasgow
UK
გაფრთხილება:
RM declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
წყაროები
ძირითადი სტატიები
Ferri C. Mixed cryoglobulinemia. Orphanet J Rare Dis. 2008 Sep 16;3:25.სრული ტექსტი აბსტრაქტი
Roccatello D, Saadoun D, Ramos-Casals M, et al. Cryoglobulinaemia. Nat Rev Dis Primers. 2018 Aug 2;4(1):11. აბსტრაქტი
American Association for the Study of Liver Diseases; Infectious Diseases Society of America. HCV guidance: recommendations for testing, managing, and treating hepatitis C. Oct 2022 [internet publication].სრული ტექსტი
Quartuccio L, Bortoluzzi A, Scirè CA, et al. Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC). Clin Rheumatol. 2023 Feb;42(2):359-70.სრული ტექსტი აბსტრაქტი
Montero N, Favà A, Rodriguez E, et al. Treatment for hepatitis C virus-associated mixed cryoglobulinaemia. Cochrane Database Syst Rev. 2018 May 7;(5):CD011403.სრული ტექსტი აბსტრაქტი
Kidney Disease: Improving Global Outcomes (KDIGO) Hepatitis C Work Group. KDIGO 2022 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int. 2022 Dec;102(6s):S129-205.სრული ტექსტი
გამოყენებული სტატიები
ამ თემაში მოხსენიებული წყაროების სრული სია ხელმისაწვდომია მომხმარებლებისთვის, რომლებსაც აქვთ წვდომა BMJ Best Practice-ის ყველა ნაწილზე.
დიფერენციული დიაგნოზები
- Small to medium vessel vasculitis
- Cryofibrinogenemia
მეტი დიფერენციული დიაგნოზებიგაიდლაინები
- Management of mixed cryoglobulinemia with rituximab
- Prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease
მეტი გაიდლაინებიპაციენტის ბროშურები
Hepatitis C: what is it?
Hepatitis C: what are the treatment options?
მეტი პაციენტის ბროშურები
შედით სისტემაში ან გამოიწერეთ BMJ Best Practice
ამ მასალის გამოყენება ექვემდებარება ჩვენს განცხადებას