Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- presence since birth
- asymmetric, indistinct or irregularly bordered, variably colored papules with diameter >5 mm
- history of change in shape and color
- asymptomatic (usually)
- multiple lesions
- flat, brown macule
- dome-shaped papule
- light brown background with speckled darker brown spots within
- blue-gray dome-shaped papule
- central pink-to-brown papule with a surrounding depigmented white ring
- pinkish-brown papule
Fatores de risco
- genetic predisposition
- fair skin
- age: older children and young adults
- ultraviolet exposure
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- dermatoscopy
Investigações a serem consideradas
- non-invasive imaging technologies
- total body photography
- biopsy
Novos exames
- whole genome sequencing
- pigmented lesion assay (PLA)
Algoritmo de tratamento
clinically benign
clinically suspicious for melanoma
Colaboradores
Autores
Jason B. Lee, MD

Professor of Dermatology & Cutaneous Biology
Clinical Vice-Chair
Director of Dermatopathology Fellowship
Director of Pigmented Lesion Clinic
Thomas Jefferson University
Philadelphia
PA
Declarações
JBL declares that he has no competing interests.
Agradecimentos
Dr Jason B. Lee would like to gratefully acknowledge Dr Laurel R. Schwartz, a previous contributor to this topic.
Declarações
LRS declares that she has no competing interests.
Revisores
Craig G. Burkhart, MD
Clinical Professor
Department of Medicine
Medical College of Ohio
Toledo
OH
Declarações
CGB declares that he has no competing interests.
Mark Hurt, MD
Dermatologist
Cutaneous Pathology
WCP Laboratories
Missouri
MO
Declarações
MH declares that he has no competing interests.
Veronique Bataille, MBBS
Consultant Dermatologist
West Herts NHS Trust and King's College London
London
UK
Declarações
VB declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Referências
Principais artigos
Duffy K, Grossman D. The dysplastic nevus: from historical perspective to management in the modern era: part I. Historical, histologic, and clinical aspects. J Am Acad Dermatol. 2012 Jul;67(1):1.e1-16. Resumo
Duffy K, Grossman D. The dysplastic nevus: from historical perspective to management in the modern era. Part II. Molecular aspects and clinical management. J Am Acad Dermatol. 2012 Jul;67(1):19.e1-12. Resumo
US Preventive Services Task Force. Final recommendation statement. Skin cancer: screening. Apr 2023 [internet publication].Texto completo Resumo
Artigos de referência
Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
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