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Superior vena cava syndrome

最后审阅: 28 Jan 2026
最后更新: 18 Jul 2023

小结

定义

病史和体格检查

关键诊断因素

  • history of smoking, pacemaker, or central venous catheter
  • localized edema of the face and upper extremities
  • dyspnea
  • facial plethora
  • cough
  • distended neck veins
  • distended chest veins
  • hoarseness of voice
  • lymphadenopathy
  • blurred vision
  • stridor
  • confusion/stupor
完整详情

其他诊断因素

  • anorexia
  • weight loss
  • hemoptysis
  • headache
  • chest pain
  • mental changes
  • fever
  • skin rash
  • arthralgia
  • laryngeal edema
  • cyanosis
  • papilledema
  • coma
完整详情

危险因素

  • smoking
  • multiple pacemaker leads
  • central venous catheters/ports
  • age >50 years
  • radiation
完整详情

诊断性检查

首要检查

  • chest x-ray
  • chest CT
  • chest MRI
  • ultrasound of upper extremities
完整详情

需考虑的检查

  • venography
  • biopsy
  • sputum cytology
  • thoracentesis
  • sputum culture
  • erythrocyte sedimentation rate
  • C-reactive protein
完整详情

治疗流程

急症处理

acute airway obstruction (without tissue diagnosis)

持续性治疗

malignant etiology

infectious etiology

iatrogenic etiology

撰稿人

作者

Kul Aggarwal, MD, MRCP, FACC
Kul Aggarwal

Professor of Clinical Medicine

University of Missouri

Columbia

MO

利益声明

KA declares that he has no competing interests.

Albert K. Chan, MD

Assistant Professor of Clinical Medicine

University of Missouri

Columbia

MO

利益声明

AKC declares that he has no competing interests.

鸣谢

Professor Kul Aggarwal and Dr Albert K Chan would like to gratefully acknowledge Dr Nipun Arora and Lokesh Tejwani, previous contributors to this topic. NA declares that he has no competing interests.

Peer reviewers

Debabrata Mukherjee, MD

Gill Foundation Professor of Interventional Cardiology

Director of Cardiac Catheterization Laboratories

Gill Heart Institute

Division of Cardiovascular Medicine

University of Kentucky

Lexington

KY

Disclosures

DM declares that he has no competing interests.

Syed Wamique Yusuf, MD, MRCPI, FACC

Associate Professor

University of Texas MD Anderson Cancer Center

Department of Cardiology

Houston

TX

Disclosures

SWY declares that he has no competing interests.

Andrew Turley, MB ChB

Cardiology Specialist Registrar

The James Cook University Hospital

Middlesbrough

UK

Disclosures

AT declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Azizi AH, Shafi I, Shah N, et al. Superior vena cava syndrome. JACC Cardiovasc Interv. 2020 Dec 28;13(24):2896-2910.Full text  Abstract

American College of Radiology. ACR appropriateness criteria: suspected upper-extremity deep vein thrombosis. 2019 [internet publication].Full text

Uberoi R. Quality assurance guidelines for superior vena cava stenting in malignant disease. Cardiovasc Intervent Radiol. 2006 May-Jun;29(3):319-22. Abstract

Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016 Feb;149(2):315-52.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Superior vena cava syndrome images
  • Differentials

    • Cardiac tamponade
    • Constrictive pericarditis
    • Acute COPD exacerbation
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  • Guidelines

    • ACR Appropriateness Criteria: suspected upper-extremity deep vein thrombosis
    • Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report
    More Guidelines
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