Last reviewed:December 2019
Last updated:May  2019

Summary

Definition

History and exam

Key diagnostic factors

  • male sex
  • history of inflammatory bowel disease

Other diagnostic factors

  • age in 40s or 50s
  • abdominal pain
  • pruritus
  • fatigue
  • weight loss
  • fever
  • jaundice
  • steatorrhea
  • splenomegaly
  • ascites
  • encephalopathy

Risk factors

  • male sex
  • inflammatory bowel disease (IBD)
  • genetic predisposition

Diagnostic investigations

Treatment algorithm

Contributors

Associate Clinical Professor

Vancouver General Hospital

University of British Columbia

Vancouver

BC

Disclosures

SIG declares that he has no competing interests.

Dr S. Ian Gan would like to gratefully acknowledge Dr Kris V. Kowdley and Dr Christine Schlenker, the previous contributors to this topic.

Peer reviewersVIEW ALL

Associate Professor of Medicine

Division of Digestive and Liver Diseases

University of Texas Southwestern Medical Center

Dallas

TX

Disclosures

MM is an author of a reference cited in this monograph.

Consultant Physician

Liver Unit

Queen Elizabeth Hospital

Birmingham

UK

Disclosures

JN declares that he has no competing interests.

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