Urticaria and angioedema

Urticaria is a skin condition characterized by erythematous, blanching, edematous, nonpainful, pruritic lesions that typically resolve within 24 hours and leave no residual markings.

Acute urticaria lasts less than 6 weeks and is often due to a hypersensitivity reaction to a specific trigger. Underlying viral infections are also a common cause of acute urticaria, particularly in children. Acute urticaria is generally self-limited.

Chronic urticaria is characterized by daily or near-daily episodes of hives occurring for 6 weeks or more and has a complex etiology.

Angioedema is swelling involving the deeper layers of the subdermis and occurs in association with urticaria in about 40% of cases. It can also occur in the absence of urticaria.

Angioedema involving the face or neck can potentially compromise the airway and requires prompt airway management.

Diagnosis of urticaria and angioedema is based on history and physical exam; diagnosis of chronic urticaria and hereditary angioedema may involve additional laboratory testing, depending on the history.

Referral to a specialist may be appropriate, especially in cases of chronic urticaria and chronic or hereditary angioedema.

Antihistamines are the mainstay of therapy for both acute and chronic urticaria. For patients who do not respond to antihistamines, additional treatment options include omalizumab and immunomodulatory therapies.

Specific treatments are available to abort acute attacks and for longer-term prophylaxis of hereditary angioedema.

Urticaria (also called hives) consists of erythematous, blanching, edematous, nonpainful, pruritic lesions that develop rapidly, usually over minutes. Urticaria typically lasts less than 24 hours and leaves no residual skin markings upon resolution.

Approximately 40% of episodes of urticaria have associated angioedema. Angioedema is a sudden, pronounced swelling of the subdermis or mucous membranes. It may be painful, rather than itchy, and last up to 72 hours.[1]Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022 Mar;77(3):734-66. https://www.doi.org/10.1111/all.15090 http://www.ncbi.nlm.nih.gov/pubmed/34536239?tool=bestpractice.com The swelling primarily affects the face, lips, mouth, upper airway, genitals, and extremities.[2]Schaefer P. Acute and chronic urticaria: evaluation and treatment. Am Fam Physician. 2017 Jun 1;95(11):717-24. https://www.aafp.org/afp/2017/0601/p717.html http://www.ncbi.nlm.nih.gov/pubmed/28671445?tool=bestpractice.com

Urticaria, with or without angioedema, may be acute or chronic. Acute episodes, which occur over a period of less than 6 weeks, are usually caused by a specific stimulus, and are self-limited. Chronic episodes occur over a period of 6 or more weeks and are rarely attributable to a specific stimulus.[3]Greaves MW. Chronic urticaria. N Engl J Med. 1995;332:1767-1772. http://www.ncbi.nlm.nih.gov/pubmed/7760895?tool=bestpractice.com

Angioedema can also occur in the absence of urticaria. This is a separate clinical entity, requiring a different diagnostic approach. Patient history, physical exam, and laboratory investigations are used to determine whether angioedema is drug-induced, hereditary, or acquired.[Figure caption and citation for the preceding image starts]: Typical lesions seen in acute or chronic urticariaFrom the collection of Stephen Dreskin, MD, PhD [Citation ends].[Figure caption and citation for the preceding image starts]: Angioedema of the lips in a patient who also has urticariaFrom the collection of Stephen Dreskin, MD, PhD [Citation ends].