Urticaria is a skin condition characterized by erythematous, blanching, edematous, nonpainful, pruritic lesions that typically resolve within 24 hours and leave no residual markings.
Acute urticaria lasts less than 6 weeks and is often due to a hypersensitivity reaction to a specific trigger. Underlying viral infections are also a common cause of acute urticaria, particularly in children. Acute urticaria is generally self-limited.
Chronic urticaria is characterized by daily or near-daily episodes of hives occurring for 6 weeks or more and has a complex etiology.
Angioedema is swelling involving the deeper layers of the subdermis and occurs in association with urticaria in about 40% of cases. It can also occur in the absence of urticaria.
Angioedema involving the face or neck can potentially compromise the airway and requires prompt airway management.
Diagnosis of urticaria and angioedema is based on history and physical exam; diagnosis of chronic urticaria and hereditary angioedema may involve additional laboratory testing, depending on the history.
Referral to a specialist may be appropriate, especially in cases of chronic urticaria and chronic or hereditary angioedema.
Antihistamines are the mainstay of therapy for both acute and chronic urticaria. For patients who do not respond to antihistamines, additional treatment options include omalizumab and immunomodulatory medications.
Specific treatments are available to abort acute attacks and for longer-term prophylaxis of hereditary angioedema.
Urticaria (also called hives) consists of erythematous, blanching, edematous, nonpainful, pruritic lesions that develop rapidly, usually over minutes. Urticaria typically lasts less than 24 hours and leaves no residual skin markings upon resolution.
Approximately 40% of episodes of urticaria have associated angioedema. Angioedema is a sudden, pronounced swelling of the subdermis or mucous membranes. It may be painful, rather than itchy, and last up to 72 hours. The swelling primarily affects the face, lips, mouth, upper airway, genitals, and extremities.
Urticaria, with or without angioedema, may be acute or chronic. Acute episodes, which occur over a period of less than 6 weeks, are usually caused by a specific stimulus, and are self-limited. Chronic episodes occur over a period of 6 or more weeks and are rarely attributable to a specific stimulus.
Angioedema can also occur in the absence of urticaria. This is a separate clinical entity, requiring a different diagnostic approach. Patient history, physical exam, and laboratory investigations are used to determine whether angioedema is drug-induced, hereditary, or acquired.
History and exam
Key diagnostic factors
- erythematous edematous lesions
- resolution within 24 hours
- swelling of face, tongue, or lips
Other diagnostic factors
- blanching lesions
- positive family history
- female sex
- exposure to drug trigger
- exposure to food trigger
- recent viral infection
- recent insect bite or sting
1st investigations to order
- CBC with differential
- erythrocyte sedimentation rate (ESR)
- C4 level
Investigations to consider
- thyroid-stimulating hormone (TSH)
- antinuclear antibodies (ANA)
- skin prick testing
- allergen avoidance diet
- serum tryptase
- skin biopsy
- C1 esterase inhibitor level
- C1 esterase inhibitor function
- C1q levels
- specific IgE to suspected allergen
acute urticaria ± angioedema
chronic urticaria ± angioedema
drug-induced angioedema without urticaria
idiopathic angioedema without urticaria
Jonathan Bernstein, MD
Professor of Medicine
Department of Internal Medicine
Division of Immunology/Allergy Section
University of Cincinnati
JB is a consultant, contracted researcher, and speaker for Sanofi-Regeneron, AstraZeneca, Novartis/Regeneron, Shire/Takeda, CSL Behring, Pharming. He is also a consultant and contracted researcher for Allakos, Kalvista, Bioscryst, IONIS. JB is a member of the Joint Task Force practice parameter. JB has spoken on this topic at National, International and Regional/Local Educational meetings. JB is an author of abstracts and manuscripts related to these topics and is an author of a number of references cited in this topic.
Dr Jonathan Bernstein would like to gratefully acknowledge Dr S. Shahzad Mustafa and Dr Stephen Dreskin, previous contributors to this topic.
SM is on the speakers' panel and advisory board for Genentech. SD declares that he has no competing interests.
Frances Humphreys, MB BS, FRCP
Honorary Associate Professor
University of Warwick
FH has attended educational events organised and funded by Almrall and Schering Plough; has received a speaker's fee from Steibel, Leo, and Schering Plough; and is an author of references cited in this topic.
Alexander M. Marsland, MRCP
Consultant in Dermatology
University Hospital of South Manchester
Luz Fonacier, MD
Head of Allergy and Training Program Director
Winthrop University Hospital
Associate Professor of Clinical Medicine
SUNY at Stony Brook
LF declares that she has no competing interests.
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