Last reviewed: March 2019
Last updated: August  2018

Summary

Differentials

Common

  • Infectious mononucleosis (Epstein-Barr virus)
  • HIV
  • Adenovirus
  • Cytomegalovirus (CMV)
  • Herpes zoster (shingles)
  • Streptococcal pharyngitis
Full details

Uncommon

  • Non-Hodgkin lymphoma
  • Hodgkin lymphoma
  • Chronic lymphocytic leukemia (CLL)
  • Metastatic solid tumor
  • Drug-associated lymphadenopathy
  • Serum sickness
  • Graft-versus-host disease (GVHD)
  • Human T-lymphotropic virus 1 (HTLV-1)
  • Mumps
  • Measles
  • Hepatitis B
  • Hepatitis C
  • Cat scratch disease
  • Tuberculosis
  • Leprosy
  • Mycobacterium avium-intracellulare (MAI)
  • Syphilis
  • Tularemia
  • Brucellosis
  • Rocky Mountain spotted fever
  • Histoplasmosis
  • Coccidioidomycosis
  • Cryptococcosis
  • Lymphogranuloma venereum (LGV)
  • Toxoplasmosis
  • Leishmaniasis
  • Systemic lupus erythematosus (SLE)
  • Rheumatoid arthritis
  • Dermatomyositis
  • Sjogren syndrome
  • Sarcoidosis
  • Crohn disease
  • Kawasaki disease
  • Castleman disease (angiofollicular lymph node hyperplasia)
  • Kikuchi disease (histiocytic necrotizing lymphadenitis)
  • Inflammatory pseudotumor
  • Progressive transformation of germinal centers
  • Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy)
  • Rubella
  • Genital herpes
  • Chancroid
  • Leptospirosis
Full details

Contributors

Authors VIEW ALL

Chief

Section of Hematology

Professor of Medicine, Thrombosis Research, and Pharmacology

Lewis Katz School of Medicine at Temple University

Department of Medicine

Philadelphia

PA

Disclosures

MEB declares that he has no competing interests.

Dr Michael E. Bromberg would like to gratefully acknowledge Dr Efrat Dotan, a previous contributor to this topic. ED declares that she has no competing interests.

Peer reviewers VIEW ALL

Consultant Hematologist

Heartlands Hospital

Birmingham

UK

Disclosures

PS declares that she has no competing interests.

Chief Fellow

Section of Hematology and Oncology

Department of Internal Medicine

Wake Forest University Baptist Medical Center

Winston-Salem

NC

Disclosures

RC declares that she has no competing interests.

Professor of Medicine

Director

Hematology Malignancies and Blood & Marrow Transplant Program

University of Colorado at Denver and Health Sciences Center

Denver

CO

Disclosures

HM declares that he has no competing interests.

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