Summary
Differentials
Common
- Infectious mononucleosis (Epstein-Barr virus)
- HIV
- Adenovirus
- Cytomegalovirus (CMV)
- Herpes zoster (shingles)
- Streptococcal pharyngitis
Uncommon
- Non-Hodgkin lymphoma
- Hodgkin lymphoma
- Chronic lymphocytic leukemia (CLL)
- Metastatic solid tumor
- Drug-associated lymphadenopathy
- Serum sickness
- Graft-versus-host disease (GVHD)
- Human T-lymphotropic virus 1 (HTLV-1)
- Mumps
- Measles
- Hepatitis B
- Hepatitis C
- Cat scratch disease
- Tuberculosis (TB)
- Leprosy
- Mycobacterium avium-intracellulare (MAI)
- Syphilis
- Tularemia
- Brucellosis
- Rocky Mountain spotted fever
- Histoplasmosis
- Coccidioidomycosis
- Cryptococcosis
- Lymphogranuloma venereum (LGV)
- Toxoplasmosis
- Leishmaniasis
- Systemic lupus erythematosus (SLE)
- Rheumatoid arthritis
- Dermatomyositis
- Sjogren syndrome
- Sarcoidosis
- Crohn disease
- Kawasaki disease
- Castleman disease (angiofollicular lymph node hyperplasia)
- Kikuchi disease (histiocytic necrotizing lymphadenitis)
- Inflammatory pseudotumor
- Progressive transformation of germinal centers
- Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy)
- Rubella
- Genital herpes
- Chancroid
- Leptospirosis
- Silicosis
Contributors
Authors
Chief
Section of Hematology
Professor of Medicine, Thrombosis Research, and Pharmacology
Lewis Katz School of Medicine at Temple University
Department of Medicine
Philadelphia
PA
Disclosures
MEB declares that he has no competing interests.
Dr Michael E. Bromberg would like to gratefully acknowledge Dr Efrat Dotan, a previous contributor to this topic.
Peer reviewers
Principal Investigator, Medical Research Council Clinician Scientist
Honorary Consultant Haematologist
Wellcome-MRC Cambridge Stem Cell Institute
University of Cambridge, Department of Haematology
The Jeffrey Cheah Biomedical Centre
Cambridge Biomedical Campus
Cambridge
UK
Disclosures
DH has received a research funding scholarship from Gilead Sciences.
Consultant Hematologist
Heartlands Hospital
Birmingham
UK
Disclosures
PS declares that she has no competing interests.
Chief Fellow
Section of Hematology and Oncology
Department of Internal Medicine
Wake Forest University Baptist Medical Center
Winston-Salem
NC
Disclosures
RC declares that she has no competing interests.
Professor of Medicine
Director
Hematology Malignancies and Blood & Marrow Transplant Program
University of Colorado at Denver and Health Sciences Center
Denver
CO
Disclosures
HM declares that he has no competing interests.
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