Cholestasis of pregnancy

May be associated with an increased risk of adverse pregnancy outcomes, including premature birth, intrauterine fetal demise, and placental abruption in severe disease.

There is an increased risk of respiratory distress syndrome in neonates, owing to meconium aspiration syndrome, which is unpredictable by available methods of surveillance.

The only definitive cure is delivery of the baby.

The condition is associated with a history of hepatitis C and there may be an association with long-term liver disease.

Mild disease with bile acid levels <40 micromol/L or mild itching can be treated with bile-sequestering agents and antihistamines, such as cholestyramine and hydroxyzine. However, if tolerated no treatment is necessary.

Severe disease with bile acid levels >40 micromol/L or severe pruritus remote from term can be treated effectively with ursodiol.

Close fetal surveillance with delivery near term can be expected with premature delivery reserved for those with severe, worsening disease despite treatment.

Intrahepatic cholestasis of pregnancy (ICP) is a pruritic condition during pregnancy caused by impaired bile flow allowing bile salts to be deposited in the skin and the placenta. The cause is a combination of hormonal, genetic, and environmental factors. ICP may predispose mothers to vitamin K deficiency and the fetus to adverse pregnancy outcomes that may include prematurity, intrauterine fetal demise, and respiratory distress syndrome.[1]Lammert F, Marschall HU, Glantz A, et al. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol. 200;33:1012-1021. http://www.ncbi.nlm.nih.gov/pubmed/11131439?tool=bestpractice.com Evidence C Obstetric adverse events: poor-quality evidence found higher incidence of respiratory distress syndrome in neonates delivered of mothers who suffered from intrahepatic cholestasis of pregnancy.[2]Poor quality observational (cohort) studies or methodologically flawed randomized controlled trials (RCTs) of <200 participants.