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Asthma in children

Last reviewed: 30 Sep 2024
Last updated: 18 Sep 2024
30 Jul 2024

GINA reiterates montelukast safety warning

The 2024 GINA guideline update reminds prescribers of the potential risk of neuropsychiatric adverse events in patients receiving montelukast, including:[1]

  • new-onset nightmares,

  • behavioral and mood problems (e.g., agitation, hyperactivity, irritability, nervousness, aggression), and

  • suicidal ideation.

Healthcare professionals should consider the benefits and risks before prescribing montelukast, and have an open discussion with parents about potential adverse effects. Healthcare professionals and patients should be alert to, and monitor for, serious behavior and mood-related changes during treatment.

See Management: approach

Original source of update

Summary

Definition

History and exam

Key diagnostic factors

  • wheezing episode triggers
  • increased work of breathing
  • features of atopic disease
  • history of response to treatment within appropriate time frame
  • family history of asthma
  • history of passive or active tobacco smoking
Full details

Other diagnostic factors

  • age >3 years
  • dry nighttime cough
  • dyspnea on exertion
  • expiratory wheezing
  • chest wall deformity
Full details

Risk factors

  • allergic sensitization
  • atopic disease
  • respiratory tract infections in early life
  • serum eosinophilia
  • family history of asthma or atopy
  • gene polymorphisms and epigenetics
  • passive or active cigarette smoking
  • vaping
  • maternal smoking in pregnancy
  • abnormal lung function and airway hyperresponsiveness
  • indoor and outdoor air pollution
  • low socioeconomic status
  • pesticide exposure
  • male sex
  • obesity
  • gastroesophageal reflux disease (GERD)
  • obstructive sleep apnea (OSA)
  • assisted reproductive technologies
  • cesarean section
  • intestinal microbiota
  • acid-suppressive drug use in pregnancy and childhood
  • acetaminophen use in pregnancy
  • antibiotic use in pregnancy
Full details

Diagnostic tests

1st tests to order

  • spirometry
  • peak expiratory flow (PEF)
  • response to bronchodilator
Full details

Tests to consider

  • airway challenge tests
  • exercise challenge test
  • CBC
  • sweat test
  • sputum culture
  • skin prick testing
  • chest x-ray
  • electron micrograph ciliary studies
  • chest CT
  • sinus CT
  • bronchoscopy
  • bronchoalveolar lavage
Full details

Emerging tests

  • fractional expired nitric oxide (FeNO)

Treatment algorithm

ONGOING

age 0 to 5 years

age 6 to 11 years

Contributors

Authors

Paul D. Robinson, MBChB, MRCPCH, FRACP, PhD, ATSF

Respiratory and Sleep Physician

Queensland Children's Hospital

Conjoint Professor

Child Health Research Centre

University of Queensland

Brisbane

Queensland

Australia

Disclosures

PDR declares that he has no competing interests.

Anne Chang, MBBS, FRACP, MPHTM, PhD, FAPSR, FThorSoc, FAHMS

Professor

Respiratory and Sleep Physician

Queensland Children's Hospital

Queensland University of Technology

Brisbane

Menzies School of Health Research

Charles Darwin University

Darwin

Australia

Disclosures

AC is an author for UptoDate and receives chapter royalties. She is an author of a number of references cited in this topic.

Peer reviewers

Kenan Haver, MD

Associate Professor of Pediatrics, Harvard Medical School

Boston Children's Hospital

Division of Pulmonary Medicine

Boston

MA

Disclosures

KH receives royalties from UpToDate.

Peter Griffiths, MBChB

General Practitioner

Harborne Medical Practice

Birmingham

UK

Disclosures

PG declares that he has no competing interests.

  • Differentials

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