Summary
Definition
History and exam
Key diagnostic factors
- age under 2 years
- immunosuppression
- high fever
- exanthem
Other diagnostic factors
- diarrhea
- abdominal pain
- Nagayama spots
- tympanic membrane inflammation
- upper respiratory symptoms
- seizures
- periorbital edema
- bulging anterior fontanelle
- cervical, occipital, or postauricular lymphadenopathy
Risk factors
- age under 2 years
- immunosuppression
Diagnostic tests
1st tests to order
- no initial test
Tests to consider
- viral culture
- antibody detection
Emerging tests
- polymerase chain reaction (PCR)
- immunohistochemistry
Treatment algorithm
all patients
Contributors
Authors
Henry M. Feder, Jr., MD
Professor of Pediatrics and Family Medicine
University of Connecticut Medical Center and Connecticut Children’s Medical Center
Farmington
CT
Disclosures
HMF declares that he has no competing interests.
Hassan El Chebib, MD
Attending Physician in the Division of Infectious Diseases and Immunology
Connecticut Children’s Medical Center
Assistant Professor of Pediatrics
Pediatrics, Infectious Diseases and Immunology
University of Connecticut School of Medicine
Hartford
CT
გაფრთხილება:
HEC declares that he has no competing interests.
Ashley C. Howard, DO
Attending Physician in the Division of Infectious Diseases and Immunology
Connecticut Children’s Medical Center
Assistant Professor of Pediatrics
Pediatrics, Infectious Diseases and Immunology
University of Connecticut School of Medicine
Hartford
CT
გაფრთხილება:
ACH declares that she has no competing interests.
მადლიერება
Dr Henry M. Feder, Dr Hassan El Chebib, and Dr Ashley C. Howard would like to gratefully acknowledge Dr Edward C. Kim, Dr Nicholas Bennett, Dr James Azim, Dr Margie C. Andreae, Dr Jon Dyer, and Dr Jennifer Holman, the previous contributors to this topic.
გაფრთხილება:
ECK, NB, JA, MCA, JD, and JH declare that they have no competing interests.
რეცენზენტები
Helen Goodyear, MBChB, MRCP, FRCPCH, MD, MMed
Consultant Paediatrician
Heartlands Hospital
Birmingham
UK
გაფრთხილება:
HG declares that she has no competing interests.
Mary T. Caserta, MD
Associate Professor of Pediatrics
Department of Pediatrics
Division of Infectious Diseases
University of Rochester Medical Center
Rochester
NY
გაფრთხილება:
MTC declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
წყაროები
ძირითადი სტატიები
Kimberlin DW, Barnett ED, Lynfield R, et al. Human herpesvirus 6 (including roseola) and 7. In: Red Book: 2021–2024 report of the Committee on Infectious Diseases. 32nd ed. Itasca, IL: American Academy of Pediatrics; 2021.
Braun DK, Dominguez G, Pellett PE. Human herpesvirus 6. Clin Microbiol Rev. 1997;10:521-67.სრული ტექსტი აბსტრაქტი
Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: a prospective study of complications and reactivation. N Engl J Med. 1994 Aug 18;331(7):432-8.სრული ტექსტი აბსტრაქტი
გამოყენებული სტატიები
ამ თემაში მოხსენიებული წყაროების სრული სია ხელმისაწვდომია მომხმარებლებისთვის, რომლებსაც აქვთ წვდომა BMJ Best Practice-ის ყველა ნაწილზე.
დიფერენციული დიაგნოზები
- Measles
- Enterovirus
- Epstein-Barr virus
მეტი დიფერენციული დიაგნოზებიგაიდლაინები
- Viral exanthems
- Human herpesvirus 6 (including roseola) and 7
მეტი გაიდლაინები
შედით სისტემაში ან გამოიწერეთ BMJ Best Practice
ამ მასალის გამოყენება ექვემდებარება ჩვენს განცხადებას