Summary
Definition
History and exam
Other diagnostic factors
- altered mental status
- headache
- nausea and/or vomiting
- gait abnormality
- ataxia
- weakness
- seizures
- visual disturbances
- speech deficit
- aphasia/dysphasia
- sensory deficit
- motor weakness
- visual change
- cranial nerve palsy
- papilledema
- personality change/emotional lability
- cognitive decline
- nystagmus
- ipsilateral dysmetria
- acalculia
- finger agnosia
- left-right confusion
- alexia (without agraphia)
- neglect
- hypothalamic syndrome
Risk factors
- white ancestry
- male gender
- neurofibromatosis type 1
- tuberous sclerosis
- Li-Fraumeni syndrome
- Turcot syndrome
- ionizing radiation
Diagnostic investigations
1st investigations to order
- ophthalmologic evaluation; visual field testing
- CT head
- MRI head
- spectroscopy MRI head
- perfusion MRI head
- biopsy
Treatment algorithm
Contributors
Authors VIEW ALL
Associate Professor of Medicine
Cleveland Clinic
Cleveland
OH
Disclosures
MSA has acted as a consultant for Elekta, Incyte, AstraZeneca, Novocure, Caris Life Sciences, Bristol-Myers Squibb, Monteris Medical, AbbVie, MRI Solutions, Elsevier, and Prime oncology. MSA has received clinical trial investigations grants from Tracon, Bristol-Myers Squibb, AstraZeneca, Novartis, and Novocure.
Professor of Neurosurgery
University of California
San Francisco
CA
Disclosures
SC has received research support from Agios, Novartis, Quest, Roche, and Schering Plough.
Dr Manmeet S. Ahluwalia and Dr Susan Chang would like to gratefully acknowledge Dr Karine Michaud, the previous contributor to this monograph. KM declares that she has no competing interests.
Peer reviewers VIEW ALL
Associate Professor
The Preston Robert Tisch Brain Tumor Center
Duke University Medical Center
Durham
NC
Disclosures
DAR declares that he has no competing interests.
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