Резюме
Определение
Анамнез и осмотр
Ключевые диагностические факторы
- at-risk demographic
- positive family history
- history of infection or exposure to oxidative drugs or broad (fava) beans
- jaundice
- pallor
- dark urine
Другие диагностические факторы
- nausea
- cataract
- splenomegaly
Факторы риска
- male sex
- neonate
- ethnic origin in the Mediterranean, sub-Saharan Africa, Middle East, or Southeast Asia
- family history
- recent exposure to oxidative drugs
- infection
- recent exposure to broad beans (favism)
Диагностические исследования
Исследования, которые показаны в первую очередь
- CBC
- reticulocyte count
- urinalysis
- unconjugated (indirect) bilirubin
- LDH
- haptoglobin
- peripheral blood smear
Исследования, проведение которых нужно рассмотреть
- G6PD fluorescent spot test
- G6PD spectrophotometry
- molecular analysis
Неотложные исследования
- point of care testing
Алгоритм лечения
acute hemolysis
neonates with prolonged indirect hyperbilirubinemia
chronic nonspherocytic hemolytic anemia
Составители
Авторы
Atul Bhanu Mehta, MA, MD, FRCP, FRCPath
Professor of Haematology and Consultant Haematologist
Royal Free Hospital and University College London School of Medicine
London
UK
Раскрытие информации
ABM declares that he has no competing interests.
Рецензенты
Lucio Luzzatto, MD
Professor of Hematology
University of Firenze
Florence
Italy
Раскрытие информации
LL declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Список литературы
Основные статьи
WHO Working Group. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ. 1989;67(6):601-11. Аннотация
Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008;371:64-74. Аннотация
Roper D, Layton M, Rees D, et al. Laboratory diagnosis of G6PD deficiency. A British Society for Haematology Guideline. Br J Haematol. 2020 Apr;189(1):24-38.Полный текст Аннотация
Luzzatto L, Nannelli C, Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Hematol Oncol Clin North Am. 2016 Apr;30(2):373-93. Аннотация
World Health Organization. Guide to G6PD deficiency rapid diagnostic testing to support P. vivax radical cure. Jul 2018 [internet publication].Полный текст
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Sickle cell disease
- Autoimmune hemolytic anemia
- Isoimmune hemolytic anemia: for example, ABO incompatibility
Больше ОтличияРекомендации
- Clinical practice guideline revision: management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation
- Laboratory diagnosis of G6PD deficiency. A British Society for Haematology Guideline
Больше РекомендацииConectar-se ou assinar para acessar todo o BMJ Best Practice
O uso deste conteúdo está sujeito ao nosso aviso legal