Diagnosis is usually clinical, based on a typical history and characteristic clinical features.
Infection typically resolves spontaneously within 10 to 14 days, and treatment is mainly supportive.
In East and Southeast Asian countries, enterovirus 71 (EV71) is responsible for a more severe version of the disease with serious complications; however, this is uncommon in the US and Europe.
A common childhood viral infection that is most commonly caused by a coxsackievirus in the US, characterized by low-grade fever, painful oral ulcers, and vesicles on the hands and feet. The disease has no relation to foot-and-mouth disease, which affects cattle and other cloven-hoofed animals.
Birmingham Children's Hospital and Birmingham City Hospital
MIO declares that she has no competing interests.
Consultant in Paediatric Infectious Diseases and Immunology
Royal Liverpool Children's Hospital (Alder Hey)
AR declares that he has no competing interests.
HG declares that she has no competing interests.
Department of Pathology and Laboratory Medicine
University of California
DC declares that he has no competing interests.
Department of Dermatology
Massachusetts General Hospital
LI declares that he has no competing interests.
Assistant Professor of Medicine
Associate Residency Program Director
University of Chicago
AS declares that she has no competing interests.
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