შეჯამება
განსაზღვრება
ანამნეზი და გასინჯვა
ძირითადი დიაგნოსტიკური ფაქტორები
- diarrhea
- bloating
- abdominal pain/discomfort
- anemia
- immunoglobulin (IgA) deficiency
- dermatitis herpetiformis
სხვა დიაგნოსტიკური ფაქტორები
- family history
- osteopenia/osteoporosis
- fatigue
- weight loss
- failure to thrive
- type 1 diabetes
- autoimmune thyroid disease
- aphthous stomatitis
- dental enamel hypoplasia
- easy bruising
- peripheral neuropathy
- ataxia
- unexplained elevation of serum aminotransferase levels
- comorbid psychiatric diagnosis
რისკფაქტორები
- family history of celiac disease
- immunoglobulin A deficiency
- type 1 diabetes
- autoimmune thyroid disease
- Down syndrome
- Turner syndrome
- Sjogren syndrome
- inflammatory bowel disease
- primary biliary cholangitis
- psoriasis
დიაგნოსტიკური კვლევები
1-ად შესაკვეთი გამოკვლევები
- immunoglobulin A-tissue transglutaminase (IgA-tTG)
- quantitative IgA
- IgG DGP (deamidated gliadin peptide)
- CBC
- endomysial antibody (EMA)
- skin biopsy
- small bowel endoscopy
- small bowel histology
გასათვალისწინებელი კვლევები
- human leukocyte antigen (HLA) typing
- gluten challenge
- video capsule endoscopy
- immunoglobulin G-tissue transglutaminase (IgG-tTG)
მკურნალობის ალგორითმი
celiac disease
failure to respond to therapy/refractory celiac disease
celiac crisis
კონტრიბუტორები
ავტორები
Amelie Therrien, MD
Gastroenterologist, Celiac Center
Instructor in Medicine, Harvard Medical School
Beth Israel Deaconess Medical Center
Boston
MA
გაფრთხილება:
AT is a site principal investigator for National Institute of Allergy and Infectious Diseases NIAID (IMX003 [latiglutenase]).
Benjamin Lebwohl, MD, MS
Associate Professor of Medicine and Epidemiology
Columbia University Irving Medical Center
New York
NY
გაფრთხილება:
BL is an unpaid advisor for Nima Partners, Takeda, Teva, 9 Meters Biopharma, Bristol Myers Squibb, Mozart Therapeutics, and Alimentiv and a contractual researcher for Anokion. BL is an author of several references in this topic.
მადლიერება
Dr Amelie Therrien and Dr Benjamin Lebwohl would like to gratefully acknowledge Professor Ciaran P. Kelly and Dr Daniel A. Leffler, previous contributors to this topic.
გაფრთხილება:
DAL declares that he has no competing interests. CPK is a scientific advisor/consultant for Cour Pharma, Glutenostics, Immunogenx, Innovate, and Takeda Pharmaceuticals. He is an investigator for Aptalis and Takeda, and has stock options in Cour Pharma and Glutenostics. CPK is also a co-author of several references cited in this topic.
რეცენზენტები
Matthew Kurien, PGDip MedSci, MD, MBChB, MRCP
Senior Clinical Lecturer and Honorary Consultant Gastroenterologist
Department of Infection, Immunity & Cardiovascular Disease
Sheffield Medical School
Sheffield
UK
გაფრთხილება:
MK declares that he has no competing interests.
Eli D. Ehrenpreis, MD
Professor of Medicine
Rosalind Franklin Medical School
Chicago
IL
გაფრთხილება:
EDE declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
წყაროები
ძირითადი სტატიები
Al-Toma A, Volta U, Auricchio R, et al. European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders. United European Gastroenterol J. 2019 Jun;7(5):583-613.სრული ტექსტი აბსტრაქტი
van der Windt DA, Jellema P, Mulder CJ, et al. Diagnostic testing for celiac disease among patients with abdominal symptoms: a systematic review. JAMA. 2010 May 5;303(17):1738-46.სრული ტექსტი აბსტრაქტი
Chaudrey KH. ACG guideline: diagnosis and management of celiac disease. Am J Gastroenterol. 2023;118(1):23. აბსტრაქტი
Husby S, Koletzko S, Korponay-Szabó I, et al. European Society for Paediatric Gastroenterology, Hepatology and Nutrition guidelines for diagnosing coeliac disease 2020. J Pediatr Gastroenterol Nutr. 2020 Jan;70(1):141-56.სრული ტექსტი აბსტრაქტი
National Institute for Health and Care Excellence. Coeliac disease: recognition, assessment and management. Sep 2015 [internet publication].სრული ტექსტი
Academy of Nutrition and Dietetics (American Dietetic Association). Celiac disease evidence-based nutrition practice guideline. 2021 [internet publication].სრული ტექსტი
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