An idiopathic inflammatory disease affecting the skin, hair, nails, and mucous membranes, usually self-limiting in nature.
Characteristic eruption consists of itchy, shiny, flat-topped violaceous papules and plaques favoring the extremities.
White net-like patches or ulceration of mucous membranes, nail deformity, scarring alopecia, and other types of skin lesions may also occur.
Most patients develop the disease between ages 30 and 60 years.
Hepatitis C infection may increase susceptibility, especially to oral disease.
Treatment may involve corticosteroids, retinoids, calcineurin inhibitors, immunosuppressants, and phototherapy.
Oxford University Hospitals Foundation Trust
Honorary Senior Clinical Lecturer
University of Oxford
SC is chair of the British Society for the Study of Vulval Disease and receives royalties for contributions to UpToDate.
Department of Dermatology
Polonnaruwa General Hospital
DM declares that she has no competing interests.
Dr Susan Cooper and Dr Deepani Munidasa would like to gratefully acknowledge Dr Rebecca Dunn, Dr Julia S. Lehman, Dr Megha M. Tollefson, and Dr Lawrence E. Gibson, previous contributors to this monograph. RD, JSL, MMT, and LEG declare that they have no competing interests.
Clinical Assistant Professor
University of Iowa College of Medicine
BS declares that he has no competing interests.
Department of Pathology and Laboratory Medicine
University of California
DC declares that he has no competing interests.
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