Evaluation of peripheral edema

Last reviewed: 2 Jun 2022
Last updated: 10 May 2022

Summary

Differentials

Common

  • Heart failure with reduced ejection fraction (HFrEF)
  • Heart failure with preserved ejection fraction (HFpEF)
  • Cor pulmonale
  • Deep vein thrombosis
  • Chronic venous insufficiency
  • Nephrotic syndrome
  • Cirrhosis
  • Pregnancy
  • Premenstrual edema
Full details

Uncommon

  • Pericardial effusion
  • Constrictive pericarditis
  • Restrictive cardiomyopathy
  • Tricuspid regurgitation
  • Sleep apnea
  • Nonthrombotic venous outflow obstruction/May-Thurner syndrome
  • Hepatic venous outflow obstruction (includes Budd-Chiari syndrome, portal vein thrombosis, and hepatic veno-occlusive disease)
  • Renal failure
  • Protein-losing enteropathy
  • Angioedema
  • Sepsis
  • Compartment syndrome
  • Primary lymphedema
  • Secondary lymphedema
  • Idiopathic
  • Severe malnutrition
  • Hypothyroidism/myxedema
  • Medication-induced edema
  • Ruptured Baker cyst
  • Pelvic tumor causing external pressure on pelvic veins
Full details

Contributors

Authors

Laura D. Rosenthal, DNP, ACNP, FAANP

Associate Professor, College of Nursing

University of Colorado Anschutz Medical Campus

Denver

CO

Disclosures

LDR declares that she has no competing interests.

Ethan Cumbler, MD

Professor of Medicine

Division of Hospital Medicine

Department of Internal Medicine

University of Colorado

Denver

CO

Disclosures

EC declares that he has no competing interests.

Peer reviewers

S. Wamique Yusuf, MD

Associate Professor

Department of Cardiology

University of Texas MD Anderson Cancer Center

Houston

TX

Disclosures

SWY declares that he has no competing interests.

Piyush Raj, MD

Basic Physician Trainee RACP

Logan Hospital

Meadowbrook

Queensland

Australia

Disclosures

PR declares that he has no competing interests.

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