Acute varicella-zoster (chickenpox) normally presents in childhood and is usually self-limiting.
Adults, pregnant women, immunosuppressed patients, and neonates are at high risk of complications from varicella, including pneumonia, neurologic sequelae, hepatitis, secondary bacterial infection, and death.
Patients in high-risk categories should receive treatment with antiviral therapy.
While most countries in Europe do not currently vaccinate children against varicella, vaccination strategies differ widely within the EU, with a few countries incorporating the vaccine into routine childhood vaccination, and others recommending it to susceptible adolescents and adults. In the US, varicella vaccine is currently recommended for immunocompetent children and susceptible adults (e.g., healthcare workers, those occupationally exposed to children, people admitted to hospital, military recruits).
Patients with high risk for severe disease who have had significant exposure to the virus and in whom the vaccine is contraindicated (i.e., neonates, pregnant women, immunocompromised people, and those receiving high-dose systemic immunosuppressive therapy) may receive immunoprophylaxis or post-exposure antiviral prophylaxis.
Varicella (chickenpox), one of the childhood exanthems, is caused by the human alpha herpes virus, varicella zoster. Varicella-zoster virus (VZV) is an exclusively human virus. The incubation period is about 14 days (range 9 to 21 days). Varicella is characterized by fever, malaise, and a generalized pruritic, vesicular rash. The disease normally presents in childhood and is usually self-limited. Adverse outcomes are more common in immunocompromised people, adolescents, adults, and pregnant women.
History and exam
Key diagnostic factors
- history of exposure
- vesicular rash
- vesicles on mucous membranes
Other diagnostic factors
- sore throat
- exposure to varicella
- age 1 to 9 years
- unvaccinated status
- occupational exposure
1st investigations to order
- clinical diagnosis
Investigations to consider
- polymerase chain reaction
- viral culture
- direct fluorescent antibody testing (DFA)
- Tzanck smear
- latex agglutination (LA)
- enzyme-linked immunosorbent assay (ELISA)
- complement fixation
- ultrasound (pregnant women)
otherwise healthy children at low risk of severe disease
increased risk of moderate to severe disease
high risk of severe disease
- Herpes zoster infection (shingles)
- Herpes simplex virus (HSV) infection
- Recommended adult immunization schedule for ages 19 years or older, United States, 2023
- Recommended child and adolescent immunization schedules for ages 18 years or younger, United States, 2023
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