Evaluation of solitary pulmonary nodule

Last reviewed: 6 Oct 2024
Last updated: 24 Jan 2024

Summary

Differentials

Common

  • Hamartoma
  • Infectious
  • Primary lung cancer
  • Metastatic cancer
  • Intrapulmonary lymph node
  • Sarcoidosis
  • Rheumatoid arthritis
  • Granulomatosis with polyangiitis (formerly known as Wegener granulomatosis)
Full details

Uncommon

  • Carcinoid tumor
  • Lymphoma
  • Arteriovenous malformation
  • Pulmonary amyloidosis
  • Mucoid impaction
Full details

Contributors

Authors

Dr George Tsaknis, MD, PhD, FRCP(London), MRQA, MAcadMEd, PGCert

Honorary Senior Lecturer

Department of Respiratory Sciences

University of Leicester

Leicester

UK

Consultant in Respiratory Medicine and Lung Cancer Lead

Clinical Director

Lung Cancer Screening Programme

Kettering General Hospital

Kettering

UK

Disclosures

GT declares that he has no competing interests.

Dr Harvinder Virk, MBChB (Hons), MA (Oxon), MRes, PhD, MRCP

NIHR Academic Clinical Lecturer in Respiratory Medicine

Department of Respiratory Sciences

University of Leicester

Leicester

UK

Disclosures

HV declares that he has no competing interests.

Acknowledgements

Dr George Tsaknis and Dr Harvinder Virk would like to gratefully acknowledge Dr Peter J. Mazzone and Dr Erik E. Folch MD, previous contributors to this topic.

Disclosures

PJM has been paid to participate in clinical advisory board meetings for Oncimmune, InDi, Nucleix, Grail, and Oncocyte, all companies interested in developing molecular biomarkers for the evaluation of lung nodules/lung cancer; he does not have a contractual agreement to disseminate product information for any of these companies. PJM has participated in research supported by InDi Veracyte, funding for which was paid to his institution. He has also participated in research with in-kind support from Oncimmune and 20/20 Genesystems. EEF is the global principal investigator for the NAVIGATE trial, sponsored by Medtronic. He has also served as scientific consultant for Boston Scientific in the development of advanced bronchoscopic techniques.

Peer reviewers

Pallav L. Shah, MD, MBBS, FRCP

Consultant Physician

Royal Brompton Hospital

Chelsea & Westminster Hospital

London

UK

Disclosures

PLS declares that he has no competing interests.

Sangeeta M. Bhorade, MD

Associate Professor of Medicine

Medical Director

Lung Transplant Program

University of Chicago Hospitals

Chicago

IL

Disclosures

SMB declares that she has no competing interests.

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