Summary
განსაზღვრება
ანამნეზი და გასინჯვა
ძირითადი დიაგნოსტიკური ფაქტორები
- previous stay in endemic area
- immunosuppression
- prolonged fever
- weight loss
- ulcerative skin lesions
- multiple nonulcerative skin nodules
- destructive mucosal inflammation
- splenomegaly
- skin darkening
სხვა დიაგნოსტიკური ფაქტორები
- fatigue
- cough
- headache
- wasting
- enlarged lymph nodes
- hepatomegaly
- previous antileishmanial treatment
- epistaxis
- abdominal pain
რისკფაქტორები
- high exposure to sand fly bites
- poverty
- proximity to a patient with a history of infection
- ownership of domestic animals
- immunosuppression
დიაგნოსტიკური კვლევები
1-ად შესაკვეთი გამოკვლევები
- CBC
- liver function tests and BUN
- serum human chorionic gonadotropin (hCG)
გასათვალისწინებელი კვლევები
- microscopic exam of relevant specimen
- blood (buffy coat) or tissue culture
- polymerase chain reaction (PCR)
- serology
- serum HIV testing
მკურნალობის ალგორითმი
cutaneous leishmaniasis (CL)
mucosal leishmaniasis (ML)
visceral leishmaniasis (VL)
post-kala-azar dermal leishmaniasis (PKDL)
relapse
კონტრიბუტორები
ავტორები
Naomi E. Aronson, MD
Professor of Medicine
Director, Infectious Diseases Division
Uniformed Services University of the Health Sciences
Bethesda
MD
გაფრთხილება:
NEA receives federal grants to study leishmaniasis (received by NEA's institution USU), has given lectures on the topic of leishmaniasis at national and international meetings, and has a patent on biomarkers for leishmaniasis. NEA's institution USU has received royalties for her writing and editorial work for UpToDate. NEA is an unpaid member for the NIH/CDC/HIVMA guidelines group (the guideline is cited in this topic), and has chaired the IDSA/ASTMH guidelines (also cited in this topic). NEA is an author of a number of references cited in this topic. The views expressed in this topic are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, the Department of Defense, or the US Government.
Nathanial K. Copeland, MD, MTM&H
Assistant Professor of Medicine
Uniformed Services University of the Health Sciences
Bethesda
MD
გაფრთხილება:
NKC is an author of a number of references cited in this topic. The views expressed in this topic are those of the authors and do not reflect the official policy of the Department of Army/Navy/Air Force, the Department of Defense, or the US Government.
მადლიერება
Professor Naomi E. Aronson and Dr Nathanial K. Copeland would like to gratefully acknowledge Professor Richard Reithinger and Professor François Chappuis, previous contributors to this topic.
გაფრთხილება:
RR and FC are authors of a number of references cited in this topic.
რეცენზენტები
Roberto Arenas, MD
Chief of the Mycology Section
Dr. Manuel Gea Gonzalez General Hospital
Mexico
გაფრთხილება:
RA is the author of an article cited in this topic.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
წყაროები
ძირითადი სტატიები
Aronson N, Herwaldt BL, Libman M, et al. Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clin Infect Dis. 2016 Dec 15;63(12):1539-57.სრული ტექსტი აბსტრაქტი
National Institutes of Health, Centers for Disease Control and Prevention, HIV Medicine Association, and Infectious Diseases Society of America. Panel on Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV. Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV: Leishmaniasis. 2024 [internet publication].სრული ტექსტი
Aronson NE, Joya CA. Cutaneous leishmaniasis: updates in diagnosis and management. Infect Dis Clin North Am. 2019 Mar;33(1):101-17. აბსტრაქტი
World Health Organization. Manual on case management and surveillance of the leishmaniases in the WHO European Region. July 2017 [internet publication].სრული ტექსტი
Chakravarty J, Sundar S. Current and emerging medications for the treatment of leishmaniasis. Expert Opin Pharmacother. 2019 Jul;20(10):1251-65. აბსტრაქტი
Pan American Health Organization. Guideline for the treatment of Leishmaniasis in the Americas. Second edition. Sep 2022 [internet publication].სრული ტექსტი
გამოყენებული სტატიები
ამ თემაში მოხსენიებული წყაროების სრული სია ხელმისაწვდომია მომხმარებლებისთვის, რომლებსაც აქვთ წვდომა BMJ Best Practice-ის ყველა ნაწილზე.
Differentials
- Hyperreactive malarial splenomegaly (HMS)
- Malaria infection
- Schistosomiasis
მეტი DifferentialsGuidelines
- CDC Yellow Book: health information for international travel - leishmaniasis
- CDC Yellow Book: health information for international travel - leishmaniasis
მეტი Guidelines
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