Osteomalacia

Osteomalacia is most commonly caused by vitamin D deficiency.

Patients frequently complain of diffuse bony pain with a history of limited sunlight exposure.

Proximal muscle weakness, spinal tenderness to percussion, pseudofractures, and skeletal deformities are found commonly.

Diagnosis is made via laboratory results with a low 25-hydroxyvitamin D level in the setting of low or normal calcium and an elevated intact parathyroid hormone (PTH) level.

Once the underlying cause is addressed, a successful treatment regimen is possible: increased sunlight exposure, oral vitamin D, and calcium replacement.

Osteomalacia is a metabolic bone disease characterized by incomplete mineralization of the underlying mature organic bone matrix (osteoid) following growth plate closure in adults.

In contrast, rickets is a metabolic bone disease characterized by defective mineralization of the epiphyseal growth plate cartilage in children, resulting in skeletal deformities and growth retardation. Rickets and osteomalacia are different manifestations of the same underlying pathologic process.