Common presenting symptoms include nausea, confusion, tremor, sweating, palpitations, or hunger. Patients may present with a nonspecific clinical history.
Documentation of a blood glucose <60 mg/dL with accompanying symptoms is crucial to diagnosing clinically significant hypoglycemia.
Important causes to consider are iatrogenic or factitious hypoglycemia secondary to insulin or sulfonylurea use. Another common cause may be physiological reactive hypoglycemia. However, the most worrisome causes are insulinoma and tumor-related hypoglycemia.
Preferred treatment for an insulinoma is surgical excision.
Hypoglycemia is a clinical syndrome present when the blood glucose concentration falls below the normal fasting glucose range, generally <60 mg/dL. When glucose values drop below the normal fasting range, glucose meters are not accurate and laboratory serum or plasma testing is useful to confirm the actual blood sugar value. Whipple triad should be present in cases of true hypoglycemia: hypoglycemic symptoms, accompanying low blood glucose concentration, and resolution of symptoms after raising the blood glucose concentration to normal.
This topic covers non-diabetic hypoglycemia in adults.
History and exam
- middle age
- female sex
- ethanol consumption
- bariatric surgery
- liver failure
- renal failure
- intense exercise
- adrenal insufficiency
- growth hormone deficiency
- glycogen storage diseases
- anorexia nervosa
- exogenous insulin
- ackee fruit ingestion
- haloperidol exposure
- quinine exposure
- fluoroquinolone exposure
- sulfonylurea exposure
- disopyramide exposure
- beta-adrenergic-blocking agent exposure
- salicylate exposure
- tramadol exposure
- proton pump inhibitor exposure
- 48 to 72 hour fast under observation
- oral glucose tolerance test
- serum insulin-like growth factor (IGF)-II
- serum adrenocorticotropic hormone
- serum human growth factor (HGH)
- insulin suppression test
- serum proinsulin
- CT scan abdomen and pelvis with and without intravenous contrast
- transabdominal ultrasound
- endoscopic ultrasound
- nuclear imaging with octreotide scan
Professor of Medicine
University of Iowa
Des Moines Internal Medicine Residency Training Program
Veterans Affairs Medical Center
UK is an author of a number of references cited in this topic.
Professor Udaya Kabadi would like to gratefully acknowledge Dr Steven Kunkel, a previous contributor to this topic.
Renal and Hypertension
Professor of Medicine
Division of Nephrology
Department of Medicine
Loyola University School of Medicine and Edward Hines Jr VA Medical Center
DJL declares that he has no competing interests.
Johns Hopkins University School of Medicine
SB declares that he has no competing interests.
Clinical Director/Clinical Lead for Diabetic Medicine
King’s College Hospital NHS Foundation Trust
DH declares that he has no competing interests.
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