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Compartment syndrome of extremities

Evidence last reviewed: 15 Oct 2026
Topic last updated: 10 Nov 2026

Summary

Definition

History and exam

Other diagnostic factors

  • pain
  • pressure (muscle tightness)
  • paresthesia
  • paralysis
Full details

Risk factors

  • trauma
  • bleeding disorder
  • compression support
  • burns and electrical injuries
  • intense muscular activity
  • prolonged abdominopelvic surgery
  • extravasation of intravenous infusion
  • venous obstruction
Full details

Diagnostic tests

1st tests to order

  • compartment pressure measurement
Full details

Tests to consider

  • serum creatine kinase
  • urine myoglobin
  • troponin
Full details

Treatment algorithm

ACUTE

acute with occlusive dressing or cast

acute without occlusive dressing or cast

ONGOING

chronic

Contributors

Authors

Dr Arvind von Keudell, MD, PhD, MPH

Orthopaedic Trauma Surgeon

Associate Professor

Brigham and Women's Hospital, Harvard Medical School

Boston, MA

Bispebjerg Hospital, University of Copenhagen

Copenhagen

Denmark

Disclosures

AK is a founder and shareholder in CustomSurg. He has consulted for Stryker, OrthoXel, and Compremium. AK is an author of one of the references cited in this topic.

Acknowledgements

Dr Arvind von Keudell would like to gratefully acknowledge Dr Miren A. Schinco and Dr Victor J. Hassid, the previous contributors to this topic.

Disclosures

MAS and VJH declare that they have no competing interests.

Peer reviewers

Jennifer Cone, MD, MHS, FACS

Assistant Professor of Surgery, Section of Trauma and Acute Care Surgery

Associate Program Director, General Surgery Residency Program

Co-Director, Military General Surgery Residency Program

Department of Surgery

The University of Chicago Medicine and Biological Sciences

Chicago, IL

Disclosures

JC declares that she has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

American Academy of Orthopaedic Surgeons. Management of acute compartment syndrome evidence-based clinical practice guideline. Nov 2025 [internet publication].Full text

British Orthopaedic Association. BOASt - diagnosis and management of compartment syndrome of the extremities. Sep 2025 [internet publication].Full text

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Differentials

    • Deep vein thrombosis
    • Stress fracture
    • Acute ischemia
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  • Guidelines

    • Diagnosis and management of acute compartment syndrome
    • Diagnosis and management of compartment syndrome of the extremities
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  • Patient information

    Burns

    More Patient information
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