Summary
Definition
History and exam
Other diagnostic factors
- pain
- pressure (muscle tightness)
- paresthesia
- paralysis
Risk factors
- trauma
- bleeding disorder
- compression support
- burns and electrical injuries
- intense muscular activity
- prolonged abdominopelvic surgery
- extravasation of intravenous infusion
- venous obstruction
Diagnostic tests
1st tests to order
- compartment pressure measurement
Tests to consider
- serum creatine kinase
- urine myoglobin
- troponin
Treatment algorithm
acute with occlusive dressing or cast
acute without occlusive dressing or cast
chronic
Contributors
Authors
Dr Arvind von Keudell, MD, PhD, MPH
Orthopaedic Trauma Surgeon
Associate Professor
Brigham and Women's Hospital, Harvard Medical School
Boston, MA
Bispebjerg Hospital, University of Copenhagen
Copenhagen
Denmark
Disclosures
AK is a founder and shareholder in CustomSurg. He has consulted for Stryker, OrthoXel, and Compremium. AK is an author of one of the references cited in this topic.
Acknowledgements
Dr Arvind von Keudell would like to gratefully acknowledge Dr Miren A. Schinco and Dr Victor J. Hassid, the previous contributors to this topic.
Disclosures
MAS and VJH declare that they have no competing interests.
Peer reviewers
Jennifer Cone, MD, MHS, FACS
Assistant Professor of Surgery, Section of Trauma and Acute Care Surgery
Associate Program Director, General Surgery Residency Program
Co-Director, Military General Surgery Residency Program
Department of Surgery
The University of Chicago Medicine and Biological Sciences
Chicago, IL
Disclosures
JC declares that she has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
References
Key articles
American Academy of Orthopaedic Surgeons. Management of acute compartment syndrome evidence-based clinical practice guideline. Nov 2025 [internet publication].Full text
British Orthopaedic Association. BOASt - diagnosis and management of compartment syndrome of the extremities. Sep 2025 [internet publication].Full text
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Deep vein thrombosis
- Stress fracture
- Acute ischemia
More DifferentialsGuidelines
- Diagnosis and management of acute compartment syndrome
- Diagnosis and management of compartment syndrome of the extremities
More GuidelinesPatient information
Burns
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