Summary
Definition
Анамнез и осмотр
Ключевые диагностические факторы
- persistent or repetitive tonic-clonic seizures with altered level of consciousness (generalized convulsive SE)
- altered awareness/confusion (nonconvulsive SE)
Другие диагностические факторы
- focal SE without impaired consciousness
- low oxygen saturation
Факторы риска
- nonadherence to anticonvulsant drugs
- alcohol-use disorder
- stroke
- refractory epilepsy
- toxic or metabolic causes
- processes leading to direct cortical structural damage
- drug use
Диагностические исследования
Исследования, которые показаны в первую очередь
- anticonvulsant drug blood level
- toxicology screen
- comprehensive metabolic panel
- CBC
- ECG
- electroencephalography (EEG)
Исследования, проведение которых нужно рассмотреть
- ABG
- CT head
- lumbar puncture
- MRI head
- continuous EEG (cEEG)
Алгоритм лечения
generalized convulsive status epilepticus
nonconvulsive status epilepticus
focal without impaired consciousness
Составители
Авторы
Emily L. Johnson, MD
Associate Professor of Neurology
Johns Hopkins Medical Institutions
Baltimore
MD
Раскрытие информации
ELJ declares that she has no competing interests.
Выражение благодарностей
Dr Emily L. Johnson would like to gratefully acknowledge Dr Ronald P. Lesser, Dr Mohammad Koubeissi, and Dr Nabil Azar, previous contributors to this topic.
Раскрытие информации
RPL or his wife have stock in the following companies, which sell health care products: Abbott Labs, Apple, Avanos, Celgene, Express Scripts, Johnson and Johnson, and Pfizer. NA declares that he has no competing interests. MK declares that he has no competing interests.
Рецензенты
Maria Jose Bruzzone Giraldez, MD
Assistant Professor Epilepsy Division
University of Florida
Gainesville
FL
Раскрытие информации
None
Yvonne Hart, MBBS
Consultant Neurologist
John Radcliffe Hospital
Oxford
UK
Раскрытие информации
YH has been reimbursed by UCB Pharma Ltd, Janssen-Cilag Ltd, Pfizer Ltd, and Eisai Ltd for attending conferences; has taught at meetings sponsored by the above companies and by GlaxoSmithKline Services Unlimited; and has received payment for advisory board work from UCB Pharma Ltd, Janssen-Cilag Ltd, Eisai Ltd, and GlaxoSmithKline Services Unlimited.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Список литературы
Основные статьи
Brophy GM, Bell R, Claassen J, et al; Neurocritical Care Society Status Epilepticus Guideline Writing Committee. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012 Aug;17(1):3-23. Аннотация
Glauser T, Shinnar S, Gloss D. Evidence-based guideline: treatment of convulsive status epilepticus in children and adults: report of the Guideline Committee of the American Epilepsy Society. Epilepsy Curr. 2016 Jan-Feb;16(1):48-61.Полный текст Аннотация
National Institute for Health and Care Excellence (UK). Epilepsies in children, young people and adults. Apr 2022 [internet publication].Полный текст
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Nonepileptic SE
- Delirium
- Coma
Больше ОтличияРекомендации
- Emergency management of the pediatric patient with convulsive status epilepticus
- Evidence-based guideline: treatment of convulsive status epilepticus in children and adults
Больше РекомендацииЛифлеты для пациента
Epilepsy: what is it?
Epilepsy: what are the treatment options?
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