Narcolepsy is a chronic condition characterized by a disruption of the sleep-wake cycle and rapid eye movement (REM) sleep intrusion.
The classic tetrad of narcolepsy, seen in only 10% to 15% of cases, includes excessive daytime sleepiness, cataplexy, sleep paralysis, and hypnagogic/hypnopompic hallucinations.
The only clinical manifestation that is specific to narcolepsy is cataplexy.
Disease onset is usually in the second decade of life.
Multiple sleep latency test usually shows shortened sleep latency and at least 2 sleep-onset REM periods.
Therapy involves lifestyle modification, stimulants for daytime sleepiness, and drug treatment for cataplexy.
Narcolepsy is a chronic sleep boundary disorder that affects the control of sleep and wakefulness with rapid eye movement sleep intrusion into the wake state. In its classic form, seen in only 10% to 15% of cases, it is characterized by a tetrad of excessive daytime sleepiness, cataplexy (generalized muscle weakness leading to partial or complete collapse), hypnagogic/hypnopompic hallucinations (visual or auditory perceptions on falling asleep or on awakening), and sleep paralysis. 
Atlanta VA Medical Center
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Sleep Disorders Center
Department of Psychiatry
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Psychiatry and Behavioral Science
Stanford University School of Medicine
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Professor of Medicine
Center for Sleep Disorders Research
Professor of Anatomy
Department of Medicine
Case Western Reserve University
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James Cook University Hospital
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