Crohn disease

Last reviewed: 25 Aug 2023
Last updated: 07 Mar 2023



History and exam

Key diagnostic factors

  • abdominal pain
  • prolonged diarrhea
  • perianal lesions
More key diagnostic factors

Other diagnostic factors

  • bowel obstruction
  • blood in stools
  • fever
  • fatigue
  • abdominal tenderness
  • weight loss
  • oral lesions
  • abdominal mass
  • extraintestinal manifestations (e.g., erythema nodosum or pyoderma gangrenosum)
Other diagnostic factors

Risk factors

  • white ethnicity and Ashkenazi Jewish ancestry
  • age 15-40 or 50-60 years
  • family history of CD
  • cigarette smoking
  • diet high in refined sugar
  • diet low in fiber
  • diet high in ultra-processed foods
  • oral contraceptives
  • not breastfed
  • nonsteroidal anti-inflammatory drugs (NSAIDs)
More risk factors

Diagnostic investigations

1st investigations to order

  • CBC
  • iron studies (serum iron, serum ferritin, total iron binding capacity [TIBC], transferrin saturation)
  • serum vitamin B12
  • serum folate
  • comprehensive metabolic panel (CMP)
  • C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)
  • stool testing
  • Yersinia enterocolitica serology
  • plain abdominal x-ray
  • MRI abdomen/pelvis
  • CT abdomen
More 1st investigations to order

Investigations to consider

  • abdominal and pelvic ultrasonography
  • ileocolonoscopy
  • tissue biopsy
  • esophagogastroduodenoscopy
  • wireless capsule endoscopy
  • fecal calprotectin or fecal lactoferrin
More investigations to consider

Emerging tests

  • serologic markers

Treatment algorithm


ileocecal disease not fistulizing with <100 cm of bowel affected: initial presentation or relapse

colonic disease not fistulizing: initial presentation or relapse

extensive small bowel disease (>100 cm of bowel affected) not fistulizing: initial presentation or relapse

upper gastrointestinal disease (esophageal and/or gastroduodenal disease) not fistulizing: initial presentation or relapse

perianal or fistulizing disease: initial presentation or relapse


in remission



George Reese, MBBS, FRCS

Consultant Colorectal Surgeon

Imperial College Healthcare NHS Trust




GR is an author of a number of references cited in this topic.

Georgia Woodfield, MBChB, MSc, PhD

Specialist Registrar in Gastroenterology and General Medicine

Imperial College Healthcare NHS Trust

Research Fellow

Imperial College London




GW declares that she has no competing interests.

Pranav H. Patel, MD

Specialist Registrar in General Surgery

Imperial College Healthcare

Research Fellow

Imperial College London




PHP declares that he has no competing interests.


Mr George Reese, Dr Georgia Woodfield, and Dr Pranav H. Patel would like to gratefully acknowledge Dr Philip J. Smith, Dr Charlotte Ford, Dr Wissam Bleibel, Dr Bishal Mainali, Dr Chandrashekhar Thukral, and Dr Mark A. Peppercorn, the previous contributors to this topic.


PJS, CF, WB, BM, CT, and MAP declare that they have no competing interests.

Peer reviewers

Kiron M. Das, MD, PhD, FACP, FRCP

Chief of Gastroenterology & Hepatology

Professor of Medicine

Director of Crohn's & Colitis Center of New Jersey

New Brunswick



KMD declares that he has no competing interests.

John Mansfield, MA, MD, FRCP

Consultant Gastroenterologist and Senior Lecturer

Royal Victoria Infirmary

Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University

Newcastle upon Tyne



JM declares that he has no competing interests.

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