Summary
Definitions
Coma is the absence of consciousness.
This state of unarousable unconsciousness includes the failure of eye opening to stimulation, a motor response no better than simple withdrawal-type movements, and a verbal response no better than simple vocalization of nonword sounds. This presupposes that the motor pathways and systems that would allow a conscious patient to respond are intact.[1]Posner JB, Saper CB, Schiff ND, et al. Psychogenic unresponsiveness. Plum and Posner's diagnosis of stupor and coma. New York, NY: Oxford University Press; 2007.[2]Wijdicks EFM. The comatose patient. New York, NY: Oxford University Press; 2007.[3]Young GB, Wijdicks EFM, eds. Disorders of consciousness. Volume 90. The Handbook of Clinical Neurology, 3rd series. New York, NY: Elsevier; 2008.
Full consciousness is an awake state in which one is aware of oneself and the environment, including the ability to perceive and interpret stimuli and to interact and communicate with others in the absence of motor deficits.
Basic alerting and wakefulness is a function of the ascending reticular activating system (ARAS).
Awareness is more complex and incompletely understood. It has multiple hierarchies (the highest probably being self-awareness and apperception) and components (e.g., perception, memory, attention, language and other symbolic coding, emotion, motivation, response selection). These components of awareness, and full conscious awareness itself, are now thought to relate to the integrated action of networks of cerebral cortical regions.[4]Sporns O. Structure and function of complex brain networks. Dialogues Clin Neurosci. 2013 Sep;15(3):247-62. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811098 http://www.ncbi.nlm.nih.gov/pubmed/24174898?tool=bestpractice.com In the assessment of conscious awareness, the Coma Recovery Scale-Revised (CRS-R) is useful in grading and tracking the level of consciousness.[5]Bodien YG, Carlowicz CA, Chatelle C, et al. Sensitivity and specificity of the coma recovery scale--revised total score in detection of conscious awareness. Arch Phys Med Rehabil. 2016 Mar;97(3):490-492.e1. http://www.ncbi.nlm.nih.gov/pubmed/26342571?tool=bestpractice.com
Brain death
The irreversible, total destruction of all brainstem functions, including the capacity for alertness, cranial nerve functions, and apnea (UK), or all brain function (whole brain death in US).
There are revised guidelines for the neurologic determination of death in infants and children.[6]Nakagawa TA, Ashwal S, Mathur M, et al. Guidelines for the determination of brain death in infants and children: an update of the 1987 task force recommendations-executive summary. Ann Neurol. 2012 Apr;71(4):573-85. http://www.ncbi.nlm.nih.gov/pubmed/22522447?tool=bestpractice.com
Brain death must never be diagnosed without an etiology.
Vegetative state (VS)
The complete loss of awareness with preserved wakefulness and wake-sleep-cycles. Thalamocortical function is severely disrupted. VS is commonly due to severe cerebral cortical damage (usually by anoxia-ischemia after cardiac arrest or less commonly by hypoglycemia), by damage to the white matter of the cerebrum (most commonly related to diffuse axonal injury from traumatic brain injury), or thalamic damage (by anoxia-ischemia or structural lesions such as tumors or strokes).
Minimally conscious state
The preservation of 1 or a very few elements of awareness: for example, behaviorally fixating or following with the eyes and reaching purposefully for an object.
Delirium
More isolated/focal aspect of impaired awareness in which attention or selection and maintenance of mental concentration is the key feature.
Alerting/wakefulness is preserved to a large degree.
Neglect syndrome
More isolated/focal aspect of impaired awareness most commonly seen with lesions of the nondominant parietal lobe or prefrontal cortex.
Alerting/wakefulness is preserved to a large degree.
Encephalopathy
Diffuse disturbance of cerebral function in the absence of overt parenchymal inflammation or structural abnormality.
There are numerous encephalopathies due to electrolyte disturbances, disturbances in thyroid function, inborn errors of metabolism (e.g., porphyria, mitochondrial disorders), organ failure (e.g., hepatic encephalopathy), systemic inflammation (e.g., due to burns), and cardiac arrest (anoxic-ischemic encephalopathy). Most of these cause reversible, functional dysfunction of the ARAS and cause a more diffuse disturbance without localizing signs.
Mass lesion
Includes brain abscess, tumor, intracerebral hemorrhage, and trauma with epidural or subdural hematoma.
Depending on case mix, mass lesions causing coma are common, especially in centers with patients with trauma, cancer, or stroke, and even in general hospitals.
It is important to recognize early phases of herniation syndromes (caused by shifts of brain structures from one compartment to another), and to investigate and treat before irreversible damage occurs. Consciousness is impaired due to compression of ARAS components.
In subfalcial herniation, the midline structures of the supratentorial space are laterally displaced, causing pressure on the thalamus and progressive impairment of consciousness with or without hemiparesis, and oculomotor palsy in later stages.
With transtentorial herniation there is downward displacement of the uncus (uncal herniation) or diencephalic structures (thalamus and hypothalamus) through the tentorial opening. This causes brainstem compression with early oculomotor palsy often before loss of consciousness.
Tonsillar herniation through the foramen magnum compresses the caudal medullary respiratory center, causing respiratory arrest and brain death.
Central (diencephalic) herniation is said to be common. Compression of the midbrain produces irreversible bilateral oculomotor palsies in later stages.
Rostrocaudal deterioration of brainstem function occurs with brainstem distortion affecting microvascular perfusion of tissue. Loss of consciousness is typically abrupt with cranial nerve palsies.
Disorders mimicking comas
Locked-in state is when consciousness is preserved but motor output is impaired (e.g., due to basis pontis lesions, severe polyneuropathies such as Guillain-Barre syndrome, pharmacologic paralysis).
Psychogenic unresponsiveness relates to lack of responsiveness due to psychogenic causes, in the absence of any toxic, metabolic, inflammatory, or structural damage to the brain (e.g., pseudocoma, pseudoseizure, psychogenic seizures).
Transient coma
Syncope (fainting) is transient coma due to the temporary reduction of global brain perfusion, which can be due to cardiac etiologies, vasomotor etiologies, orthostatic hypotension, or pulmonary embolism.
Seizures produce transient coma due to epileptiform discharges in the brain, either as absence/petit mal seizures (bifrontal or diffuse cortical and thalamic involvement), complex partial seizures (usually of temporal lobe origin, associated with diffuse limbic involvement and cerebral cortical inhibition), or generalized convulsive seizures (with seizure discharges involving both cerebral hemispheres and brainstem structures). Coma can be prolonged in status epilepticus (e.g., nonconvulsive status epilepticus as diagnosed by EEG). Convulsive movements and incontinence can occur, especially with generalized tonic-clonic seizures.
Concussion is the transient loss of consciousness after a blow to the head.
Pathophysiology
Alerting or arousal is a function of the ARAS. Arousal to wakefulness is a prerequisite for awareness. This arousal system is anatomically represented by several structures in the rostral brainstem tegmentum, the diencephalon, and projections to the cerebral cortex.[7]Vincent SR. The ascending reticular activating system - from aminergic neurons to nitric oxide. J Chem Neuroanat. 2000 Feb;18(1-2):23-30. http://www.ncbi.nlm.nih.gov/pubmed/10708916?tool=bestpractice.com Principal among these are acetyl choline-producing neurons in the rostral brainstem. These project rostrally in 2 major pathways that also contribute to cortical arousal:[7]Vincent SR. The ascending reticular activating system - from aminergic neurons to nitric oxide. J Chem Neuroanat. 2000 Feb;18(1-2):23-30. http://www.ncbi.nlm.nih.gov/pubmed/10708916?tool=bestpractice.com
A dorsal pathway that synapses with the midline and nonspecific thalamic nuclei, which then send a glutaminergic projection to large areas of the cerebral cortex
A ventral pathway from the rostral brainstem tegmentum that reaches the basal forebrain, especially the posterior hypothalamus, where axon terminals act on neurons that synthesize histamine, hypocretin, or orexin.
The ARAS is a complex system with some redundancy of pathways that are involved in arousal and maintenance of wakefulness. This may explain the recovery of the arousal system after initial coma, almost always within 3 weeks from coma onset in most patients. As a corollary, disorders cause impaired consciousness by impairing the function of a significant component of the ARAS.
Epidemiology
Although transient episodes of unconsciousness (e.g., faint, seizure) are common and account for about 5% of emergency room visits, in-hospital consultations for coma constitute only 0.02% of admissions in England.[8]Department of Health. Hospital Episode Statistics (England). 2002-2003 [internet publication]. http://www.hscic.gov.uk/hes Adult men and women are almost equally affected. The mean age is 57 years, although >35% of patients with coma are >75 years of age.[8]Department of Health. Hospital Episode Statistics (England). 2002-2003 [internet publication]. http://www.hscic.gov.uk/hes
Prevention and management
Initial management steps include airway, breathing, and circulatory (ABC) support. In the unresponsive patient, airway protection is paramount.[9]Matthes G, Bernhard M, Kanz KG, et al. Emergency anesthesia, airway management and ventilation in major trauma. Background and key messages of the interdisciplinary S3 guidelines for major trauma patients [in German]. Unfallchirurg. 2012 Mar;115(3):251-64. http://www.ncbi.nlm.nih.gov/pubmed/22406918?tool=bestpractice.com
Clinical assessment tools for patients with impaired consciousness, include the Glasgow Coma Scale and the Full Outline of UnResponsiveness (FOUR) scoring system; the latter has some advantages in intubated patients.[10]Bruno MA, Ledoux D, Lambermont B, et al. Comparison of the Full Outline of UnResponsiveness and Glasgow Liege Scale/Glasgow Coma Scale in an intensive care unit population. Neurocrit Care. 2011 Dec;15(3):447-53. http://www.ncbi.nlm.nih.gov/pubmed/21526394?tool=bestpractice.com
Guidelines and analyses have informed the prevention and management of ischemic stroke, subarachnoid hemorrhage, intracerebral hemorrhage, and trauma.[11]Meschia JF, Bushnell C, Boden-Albala B, et al; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; Council on Hypertension. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014 Dec;45(12):3754-832. http://stroke.ahajournals.org/content/45/12/3754.long http://www.ncbi.nlm.nih.gov/pubmed/25355838?tool=bestpractice.com [12]Lansberg MG, Bluhmki E, Thijs VN. Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis. Stroke. 2009 Jul;40(7):2438-41. http://www.ncbi.nlm.nih.gov/pubmed/19478213?tool=bestpractice.com [13]Connolly ES Jr, Rabinstein AA, Carhuapoma JR, et al; American Heart Stroke Council; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2012 Jun;43(6):1711-37. http://stroke.ahajournals.org/content/43/6/1711.long http://www.ncbi.nlm.nih.gov/pubmed/22556195?tool=bestpractice.com [14]Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 guideline for the management of patients with spontaneous intracerebral hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2022 Jul;53(7):e282-e361. https://www.ahajournals.org/doi/abs/10.1161/STR.0000000000000407 http://www.ncbi.nlm.nih.gov/pubmed/35579034?tool=bestpractice.com [15]Steiner T, Al-Shahi Salman R, Beer R, et al; European Stroke Organisation. European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage. Int J Stroke. 2014 Oct;9(7):840-55. http://www.ncbi.nlm.nih.gov/pubmed/25156220?tool=bestpractice.com [16]Pandor A, Harnan S, Goodacre S, et al. Diagnostic accuracy of clinical characteristics for identifying CT abnormality after minor brain injury: a systematic review and meta-analysis. J Neurotrauma. 2012 Mar 20;29(5):707-18. http://www.ncbi.nlm.nih.gov/pubmed/21806474?tool=bestpractice.com [17]Kim YJ. A systematic review of factors contributing to outcomes in patients with traumatic brain injury. J Clin Nurs. 2011 Jun;20(11-12):1518-32. http://www.ncbi.nlm.nih.gov/pubmed/21453293?tool=bestpractice.com The use of pharmacological and electrical stimulation in cases of vegetative and minimally conscious states remains controversial.[18]Oliveira L, Fregni F. Pharmacological and electrical stimulation in chronic disorders of consciousness: new insights and future directions. Brain Inj. 2011;25(4):315-27. http://www.ncbi.nlm.nih.gov/pubmed/21314279?tool=bestpractice.com
Differentials
Common
- Stroke
- Cardiac arrest
- Hypertensive encephalopathy
- Basilar artery thrombosis
- Cerebral venous thrombosis
- Alcohol abuse
- Substance abuse and overdose
- Carbon monoxide poisoning
- Sepsis-associated encephalopathy
- Bacterial meningitis
- Syncope
- Seizure disorder
- Traumatic brain injury
- Hypoglycemia
- Hyperglycemia
- Hepatic encephalopathy
- Hyponatremia
- Hypothyroidism
- Wernicke encephalopathy
- Hypophosphatemia
Uncommon
- Subarachnoid hemorrhage
- Encephalitis
- Brain abscess
- Brain tumor
- Hypernatremia
- Hypercalcemia
- Hypocalcemia
- Hypermagnesemia
- Hypomagnesemia
- Porphyria
- Mitochondrial disorder
- Thyroid storm
- Burns
- Hyperthermia
- Hypothermia
- Psychogenic unresponsiveness
- Locked-in state
Contributors
Authors
G. Bryan Young, MD, FRCPC

Professor of Neurology
University of Western Ontario
ON
Canada
Disclosures
GBY declares that he has no competing interests.
Peer reviewers
Paul Vespa, MD
Professor of Neurology and Neurosurgery
Director of Neurocritical Care
David Geffen School of Medicine at University of California
LA
Disclosures
PV declares that he has no competing interests.
Steven Laureys, MD, PhD
Department of Neurology
Liege University Hospital
Head
Coma Science Group
Senior Research Associate
Belgian National Funds for Scientific Research
Cyclotron Research Centre
University of Liege
Belgium
Disclosures
SL declares that he has no competing interests.
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