Primary manifestation of lymphogranuloma venereum infection is painless penile or vulvar inflammation and ulceration at the site of inoculation; often not noticed by the patient.
Secondary stage typically occurs weeks after development of the primary lesion; presents as painful, unilateral, inguinal or femoral lymphadenopathy (often referred to as "inguinal syndrome").
Proctocolitis has emerged as a more typical presentation in men who have sex with men (particularly those who are HIV-positive).
Chronic inflammation can lead to scarring and fibrosis causing lymphedema of the genitals, or formation of strictures and fistulae if anorectal involvement.
Identification of Chlamydia trachomatis from the swab of a genital ulcer or aspiration of a bubo is definitive diagnosis.
Doxycycline is the preferred first-line treatment; macrolides are an alternative treatment option (e.g., in pregnant or lactating women, or patients with allergies to tetracyclines).
Large buboes may be aspirated, but incision and drainage or surgical excision of buboes may complicate healing.
Lymphogranuloma venereum (LGV) is a STI caused by Chlamydia trachomatis genovars/serovars L1, L2, or L3 (collectively termed the "LGV biovar"), which are endemic to the tropics, but now emerging in developed regions. Infection occurs through contact with mucous membranes or abrasions in the skin of the genital region.
History and exam
Key diagnostic factors
- inguinal lymphadenopathy
- nonspecific symptoms of proctocolitis
- groove sign of Greenblatt
- genital elephantiasis, saxophone penis, esthiomene
Other diagnostic factors
- fever, malaise, arthralgias
- lower abdominal or lower back pain
- genital or anal ulcer
- nonspecific symptoms of bacteremic spread
- erythema nodosum
- anogenital sinus tracts, strictures, or fistulae
- other STIs
- risky sexual behavior
- age (20 to 40 years)
- unprotected intercourse in an area endemic for LGV
1st investigations to order
- genital or lymph node specimens for nucleic acid amplification testing (NAAT)
- swab via anoscopy for Gram staining
- fluid or swab for LGV-specific molecular testing
- STI testing
Investigations to consider
- endoscopy with histopathology
- serum for complement fixation
- serum for microimmunofluorescence (MIF)
- CT of abdomen and pelvis
- MRI of abdomen and pelvis
- fluid or swab for culture
- fluid or swab for genovar typing
asymptomatic adolescent and adult patients who have been exposed to lymphogranuloma venereum (LGV)
all stages of lymphogranuloma venereum (LGV)
- Syphilis (Treponema pallidum)
- Gonococcal proctitis
- Genital herpes (HSV)
- Sexually transmitted infections treatment guidelines, 2021
- 2019 European guideline on the management of lymphogranuloma venereum
ChlamydiaMore Patient leaflets
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