Primary manifestation of infection is painless penile or vulvar inflammation and ulceration at the site of inoculation; often not noticed by patient.
Secondary stage typically occurs weeks after development of the primary lesion; presents as painful, unilateral, inguinal or femoral lymphadenopathy (often referred to as "inguinal syndrome").
Proctocolitis has emerged as a more typical presentation in men who have sex with men (particularly those who are HIV-positive).
Chronic inflammation can lead to scarring and fibrosis causing lymphedema of the genitals, or formation of strictures and fistulae if anorectal involvement.
Identification of Chlamydia trachomatis from the swab of a genital ulcer or aspiration of a bubo is definitive diagnosis.
Doxycycline is the preferred first-line treatment; macrolides are an alternative treatment option (e.g., in pregnant or lactating women, or patients with allergies to tetracyclines).
Large buboes may be aspirated, but incision and drainage or surgical excision of buboes may complicate healing.
Lymphogranuloma venereum (LGV) is a STD caused by Chlamydia trachomatis serovars L1, L2, or L3, which are endemic to the tropics, but rare in developed regions. Infection occurs through contact with mucous membranes or abrasions in the skin of the genital region.
Division of Hospital Medicine
MedStar Georgetown University Hospital
BDL declares that he has no competing interests.
Dr Benjamin D. Lorenz would like to gratefully acknowledge Dr Mettassebia Kanno, a previous contributor to this monograph. MK declares that she has no competing interests.
Department of General Internal Medicine
Leiden University Medical Centre
CvN declares that he has no competing interests.
Department of Obstetrics and Gynecology
Virginia Commonwealth University
DC declares that he has no competing interests.
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