Evaluation of fever of unknown origin in adults

Evidence last reviewed: 26 Mar 2026
Topic last updated: 21 Apr 2026

Summary

Diagnósticos diferenciais

comuns

  • Tuberculosis (TB)
  • Abdominal or pelvic abscess
  • HIV
  • Rhinosinusitis, acute or chronic
  • Bacterial pneumonia
  • Urinary tract infection
Detalhes completos

Incomuns

  • Infective endocarditis
  • Dental abscesses
  • Osteomyelitis
  • Prostatitis, acute or chronic
  • Cytomegalovirus infection
  • Epstein-Barr virus infection
  • Coronavirus disease 2019 (COVID-19)
  • Rheumatic fever
  • Lyme disease
  • Chronic myeloid leukemia
  • Hodgkin lymphoma
  • Non-Hodgkin lymphoma
  • Metastatic carcinoma, primary unknown
  • Renal cancer
  • Myelodysplastic syndrome
  • Adult-onset Still disease
  • Polymyalgia rheumatica
  • Giant cell arteritis
  • Systemic lupus erythematosus
  • Crohn disease
  • Ulcerative colitis
  • Rheumatoid arthritis
  • Reactive arthritis
  • Drug-induced fever
  • Cirrhosis, complicated
  • Hepatitis
  • Deep vein thrombosis
  • Sarcoidosis
  • Periodic fever syndromes
  • Malaria
  • Typhoid fever
  • Rocky Mountain spotted fever
  • Ascariasis
  • Tularemia
  • Brucellosis
  • Psittacosis
  • Q fever
  • Pheochromocytoma
  • Hyperthyroidism
  • Munchausen syndrome
  • Dengue fever
Detalhes completos

Colaboradores

Autores

William F. Wright, DO, MPH

Assistant Professor

Division of Infectious Diseases, Department of Medicine

Johns Hopkins University School of Medicine

Baltimore, MD

Declarações

WFW declares that he has no competing interests.

Paul G. Auwaerter, MD

Professor

Division of Infectious Diseases, Department of Medicine

The Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases

Johns Hopkins University School of Medicine

Baltimore, MD

Declarações

PGA has equity holdings in Johnson & Johnson, and does ongoing Lyme disease vaccine research funded by Pfizer. He has been a consultant to Shionogi regarding coronavirus disease and is on the board of directors for Capricor, which has an investigational product for Duchenne muscular dystrophy. He has an unpaid position on the board of directors for the American Lyme Disease Foundation.

Agradecimentos

Dr William F. Wright and Dr Paul G. Auwaerter would like to gratefully acknowledge Dr Roth and Dr Basello, previous contributors to this topic.

Revisores

Kevin P. High, MD, MS, MACP, FIDSA

Professor of Medicine

Wake Forest University School of Medicine

Vice Chief Academic Officer, aLHS, Advocate Health

Winston-Salem, NC

Declarações

KPH declares that he has no competing interests.

Créditos aos pareceristas

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Referências

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Principais artigos

Haidar G, Singh N. Fever of unknown origin. N Engl J Med. 2022 Feb 3;386(5):463-77. Resumo

Cunha BA, Lortholary O, Cunha CB. Fever of unknown origin: a clinical approach. Am J Med. 2015 Oct;128(10):1138.e1-1138.e15.Texto completo  Resumo

Wright WF, Auwaerter PG. Fever and fever of unknown origin: review, recent advances, and lingering dogma. Open Forum Infect Dis. 2020 May;7(5):ofaa132.Texto completo  Resumo

Artigos de referência

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