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Erythema multiforme

Last reviewed: 19 Aug 2025
Last updated: 18 Oct 2024

Summary

Definition

Анамнез и осмотр

Ключевые диагностические факторы

  • target lesions of the extremities
  • previous episode of EM
  • mucosal erosions
Полная информация

Другие диагностические факторы

  • targetoid lesions
  • rapid onset of lesions
  • self-limiting course
  • clustered vesicles on an erythematous base
  • rhonchi, rales, and/or wheezes
  • red tympanic membranes
Полная информация

Факторы риска

  • prior episode of erythema multiforme
  • herpes simplex virus (HSV) infection
  • certain other infections
  • Mycoplasma pneumonia infection
  • lymphoma
  • Kawasaki disease
  • use of certain medications
  • vaccinations
  • tattoos
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • clinical diagnosis
Полная информация

Исследования, проведение которых нужно рассмотреть

  • hematoxylin and eosin biopsy
  • immunofluorescence biopsy
  • CBC
  • serum electrolytes
  • herpes simplex virus (HSV) serology
  • rapid polymerase chain reaction (PCR)
  • cold-hemagglutination serology
  • M pneumoniae titers
  • CXR
  • autoantibody titers
Полная информация

Неотложные исследования

  • antidesmoplakin antibodies

Алгоритм лечения

Острый

EM minor

EM major

ПРОДОЛЖЕНИЕ

recurrent EM

Составители

Авторы

Nathan W. Rojek, MD, FAAD

Assistant Professor

Director, Inpatient Dermatology

Department of Dermatology

University of California, Irvine

Irvine

CA

Раскрытие информации

NWR declares that he has no competing interests.

Выражение благодарностей

Dr Nathan W. Rojek would like to gratefully acknowledge Dr Areta Kowal-Vern, Dr Jonathan Silverberg, and Dr Nanette Silverberg, the previous contributors to this topic.

Раскрытие информации

AK-V, JS, and NS declare that they have no competing interests.

Рецензенты

Cristine Radojicic, MD

Staff Physician

Cleveland Clinic

Cleveland

OH

Раскрытие информации

CR declares that she has no competing interests.

Brian Swick, MD

Clinical Assistant Professor

University of Iowa College of Medicine

Iowa City

IA

Раскрытие информации

BS declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Список литературы

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Основные статьи

Lerch M, Mainetti C, Terziroli Beretta-Piccoli B, Harr T. Current perspectives on erythema multiforme. Clin Rev Allergy Immunol. 2018 Feb;54(1):177-84. Аннотация

Grünwald P, Mockenhaupt M, Panzer R, et al. Erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis - diagnosis and treatment. J Dtsch Dermatol Ges. 2020 Jun;18(6):547-53. Аннотация

Soares A, Sokumbi O. Recent updates in the treatment of erythema multiforme. Medicina (Kaunas). 2021 Sep 1;57(9):921.Полный текст  Аннотация

de Risi-Pugliese T, Sbidian E, Ingen-Housz-Oro S, et al. Interventions for erythema multiforme: a systematic review. J Eur Acad Dermatol Venereol. 2019 May;33(5):842-9. Аннотация

Статьи, указанные как источники

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