Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- postpubertal age
- positive family history of GS
- icterus (jaundice)
- absence of hepatosplenomegaly
- no stigmata of chronic liver disease
Fatores de risco
- postpubertal age
- family history of GS
- type 1 diabetes mellitus
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- unconjugated bilirubin
- liver aminotransferases
- gamma-glutamyl transpeptidase
- lactate dehydrogenase
- CBC
- peripheral blood smear
- direct Coombs' test
Investigações a serem consideradas
- liver biopsy
- plasma unconjugated bilirubin response to fasting
- plasma unconjugated bilirubin response to nicotinic acid
- UGT1A1 genotyping
- UDPGT enzyme activity
Algoritmo de tratamento
all patients
Colaboradores
Autores
Nathalie Khoury, MD
Clinical Fellow - Transplant Hepatology
University of Nebraska Medical Center
Omaha
NE
Declarações
NK declares that she has no competing interests.
Marco A. Olivera-Martinez, MD, FACP, FAASLD
Professor of Medicine
Gastroenterology & Hepatology
University of Nebraska Medical Center
Omaha
NE
Раскрытие информации
MAOM declares that he has no competing interests.
Выражение благодарностей
Dr Marco A. Olivera-Martinez would like to gratefully acknowledge Dr Brian Ward and Dr John L. Gollan, the previous contributors to this topic.
Раскрытие информации
BW declares that he has no competing interests. JLG is an author of a reference cited in the topic.
Рецензенты
Lefkothea P. Karaviti, MD, PhD
Professor of Pediatrics
Division of Endocrinology and Metabolism
Baylor College of Medicine
Texas Children's Hospital
Houston
TX
Раскрытие информации
LPK declares that she has no competing interests.
John T. Jenkins, MB, CHB, FRCP
Consultant Surgeon
St. Mark's Hospital
London
UK
Раскрытие информации
JTJ declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Список литературы
Основные статьи
Bosma PJ, Chowdhury JR, Bakker C, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med. 1995 Nov 2;333(18):1171-5.Полный текст Аннотация
King D, Armstrong MJ. Overview of Gilbert's syndrome. Drug Ther Bull. 2019 Feb;57(2):27-31. Аннотация
Kwo PY, Cohen SM, Lim JK. ACG clinical guideline: evaluation of abnormal liver chemistries. Am J Gastroenterol. 2017 Jan;112(1):18-35.Полный текст Аннотация
Статьи, указанные как источники
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Отличия
- Hemolysis
- Cirrhosis
- Cardiac disease (e.g., congenital heart disease and valvular heart disease)
Больше Отличия
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