Summary
Definition
History and exam
Key diagnostic factors
- history of stroke(s)
- difficulty solving problems
- apathy
- disinhibition
- slowed processing of information
- poor attention
- retrieval memory deficit
- frontal release reflexes
- focal neurologic signs
- impaired gait and balance
Risk factors
- age >60 years
- obesity
- hypertension
- cigarette smoking
- diabetes mellitus
- hypercholesterolemia
- alcohol misuse
- chronic kidney disease
Diagnostic tests
1st tests to order
- CBC
- erythrocyte sedimentation rate
- blood glucose level
- renal and liver function tests
- vitamin B12
- folate
- thyroid function
- MRI brain
- ECG
- neuropsychologic testing
Tests to consider
- syphilis serology
- lupus anticoagulant, antiphospholipid, and antinuclear testing
- carotid duplex ultrasound
- echocardiogram
Treatment algorithm
atherosclerotic ischemic disease
cardioembolic disease
Contributors
Authors
Peter Passmore, BSc, MB, BCh, BAO, MD, FRCP (Lond, Glasg), FRCPI
Professor of Ageing and Geriatric Medicine
Queen's University Belfast
Belfast
UK
Disclosures
PP declares that he has no competing interests.
Acknowledgements
Dr Peter Passmore would like to gratefully acknowledge Dr David Wilson, Dr Grant Bateman, and Dr Velandai Srikanth, previous contributors to this topic.
Disclosures
DW has received educational grants from Shire. GB and VS declare that they have no competing interests.
Peer reviewers
Roy J. Goldberg, MD, FACP, AGSF, CMD
Medical Director
Kings Harbor Multicare Center
New York
NY
利益声明
RJG declares that he has no competing interests.
Craig N. Sawchuk, PhD
Affiliate Assistant Professor
Department of Psychiatry and Behavioral Sciences
University of Washington Medical Center
Seattle
WA
利益声明
CNS declares that he has no competing interests.
Bryan Bernard, PhD
Assistant Professor and Clinical Neuropsychologist
Department of Neurological Sciences
Rush University Medical Center
Chicago
IL
利益声明
BB declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
Hachinski V, Iadecola C, Petersen RC, et al. National Institute of Neurological Disorders and Stroke - Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006 Sep;37(9):2220-41.全文 摘要
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.
American College of Radiology. ACR appropriateness criteria: dementia. 2024 [internet publication].全文
Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke. 2021 Jul;52(7):e364-467.全文
参考文献
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
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