Summary
Definition
History and exam
Other diagnostic factors
- unexplained fevers
- night sweats
- weight loss
- dyspnea
- cough
- chest pain
- superior vena cava syndrome
- abdominal pain
- generalized pruritus
- alcohol-induced pain at involved sites
- hepatomegaly and/or splenomegaly
- tonsillar enlargement
Risk factors
- history of Epstein-Barr virus (EBV) infection
- family history of Hodgkin lymphoma
- young adults from higher socioeconomic class
- HLA types
- Jewish ancestry
Diagnostic investigations
1st investigations to order
- CBC with differential
- metabolic panel
- erythrocyte sedimentation rate (ESR)
- CXR
- PET-CT scan
- gallium scan
- contrast CT neck, chest, and abdomen/pelvis
- excisional lymph node biopsy
- immunohistochemical studies
Investigations to consider
- bone marrow biopsy
- thyroid function tests
- echocardiogram or multigated acquisition (MUGA) scan
- pulmonary function tests
Treatment algorithm
Contributors
Authors
Assistant Attending
Lymphoma Service
Memorial Sloan-Kettering Cancer Center
New York City
NY
Disclosures
AM has received honoraria for serving on advisory boards for Seattle Genetics, BMS, Merck, and Erytech. She has received honoraria from Seattle Genetics and Takeda for educational lectures.
Dr Alison Moskowitz would like to gratefully acknowledge Dr Chris R. Kelsey, Dr Leonard R. Prosnitz, and Dr Timothy M. Zagar, the previous contributors to this topic.
Peer reviewers
Radiation Oncologist
Director of Postgraduate Education
Department of Radiation Oncology
Memorial Sloan-Kettering Cancer Center
New York
NY
Disclosures
JY declares that he has no competing interests.
Chief Fellow
Section of Hematology and Oncology
Department of Internal Medicine
Wake Forest University Baptist Medical Center
Winston-Salem
NC
Disclosures
RC declares that she has no competing interests.
Consultant Haematologist
University College London Hospitals
London
UK
Disclosures
KA declares that he has no competing interests.
Use of this content is subject to our disclaimer