Summary
Definition
History and exam
Key diagnostic factors
- chest pain
- chest-wall tenderness
Other diagnostic factors
- chest-wall swelling
Risk factors
- microtrauma
- female sex
- age >40 years
- sternotomy wound infection
- intravenous drug use
Diagnostic tests
1st tests to order
- nonsteroidal anti-inflammatory drug trial
Tests to consider
- local anesthetic and corticosteroid trial
- chest x-ray
- CT chest
- MRI chest
- wound or blood cultures
Treatment algorithm
inflammatory
infectious
Contributors
Authors
Fadi Badlissi, MD, MSc

Attending Physician
Medical Director of the Musculoskeletal Medical Unit
Department of Orthopedics & Division of Rheumatology
Beth Israel Deaconess Medical Center
Assistant Professor of Medicine
Harvard Medical School
Boston
MA
Disclosures
FB has been reimbursed by ANI Pharmaceuticals and Janssen and Amgen for attending an advisory board meeting.
Peer reviewers
Don L. Goldenberg, MD
Emeritus Professor of Medicine
Tufts University School of Medicine
Boston
MA
Disclosures
DLG declares that he has no competing interests.
Richard G. Chang, MD, MPH, FAAPMR
Associate Program Director
Sports Medicine Fellowship
Assistant Professor of Medicine
Icahn School of Medicine at Mount Sinai
New York
NY
Disclosures
RGC declares that he is the President of the New York Society Of Physical Medicine and Rehabilitation (2023-2025), is State Advocacy Chair and a Health Policy and Legislative Committee member for the American Academy of Physical Medicine and Rehabilitation, and is a Health Policy Division and Ultrasound Education Committee member for the Spine Intervention Society.
Richard Wakefield, BM, FRCP, MD
Senior Lecturer in Rheumatology
Section of Musculoskeletal Disease
Leeds Institute of Molecular Medicine
Chapel Allerton Hospital
Leeds
UK
Disclosures
RW declares that he has no competing interests.
References
Key articles
Mott T, Jones G, Roman K. Costochondritis: rapid evidence review. Am Fam Physician. 2021 Jul 1;104(1):73-8.Full text
Proulx AM, Zryd TW. Costochondritis: diagnosis and treatment. Am Fam Physician. 2009 Sep 15;80(6):617-20.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
Differentials
- Acute coronary syndrome
- Pleuritis
- Pulmonary embolism
More DifferentialsGuidelines
- Appropriateness criteria: nontraumatic chest wall pain
More GuidelinesLog in or subscribe to access all of BMJ Best Practice
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