证据
本页包含特色内容的快照，内容强调了探讨关键临床问题的证据，包括不确定性领域。敬请参阅主要专题参考文献列表，了解支持该专题的所有信息源详情。
BMJ Best Practice 临床实践证据表单
该表单为 Cochrane Clinical Answer 针对上述重要临床问题所报道的分析总结。
Confidence in the evidence is moderate or low to moderate where GRADE has been performed and there may be no difference in effectiveness between the intervention and comparison for key outcomes.
人群： Children or adults with acute bacterial meningitis ᵃ
干预： Glycerol with or without corticosteroids ᵇ
比较： Placebo with or without corticosteroids ᵇ
| 结局 | 效能（BMJ 评价）? | 证据可信度（GRADE）? |
|---|---|---|
Mortality (follow‐up up to 6 months) | No statistically significant difference | Moderate |
Neurological disability (follow‐up 40 days to 6 months) | No statistically significant difference | Low |
Seizures (follow‐up 40 days to 6 months) | No statistically significant difference | Low |
Hearing loss (follow‐up 40 days to 6 months) | Favors intervention ᶜ | Moderate |
Adverse effects: nausea, vomiting, diarrhea | No statistically significant difference | Very Low |
Adverse effects: gastrointestinal bleeding | No statistically significant difference | Moderate |
注意 The Cochrane Review which underpins this Cochrane Clinical Answer (CCA) notes that glycerol may provide a small beneficial effect for deafness in children. However, further research is required. ᵃ Of the five included studies, four were in children (age range 2 months to 16 years) and one in adults (age range not reported). See CCA for more details. ᵇ All participants received broad-spectrum antibiotics. ᶜ Subgroup analysis found no statistically significant difference between groups for participants who received corticosteroids. See CCA for more details.
该证据表单关联以下章节：
Cochrane Clinical Answers
Cochrane Clinical Answers（CCAs）来自 Cochrane 系统评价，注重临床，通俗易懂，实操性强，可为即时诊疗决策提供参考信息，收录于 BMJ Best Practice 临床实践。
- How does glycerol compare with placebo for people with acute bacterial meningitis treated with antibiotics?
内容使用需遵循免责声明