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Hepatitis E

Última revisão: 9 Apr 2025
Última atualização: 13 Mar 2024

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • jaundice/scleral icterus
  • asterixis
Detalhes completos

Outros fatores diagnósticos

  • asymptomatic
  • malaise
  • fatigue
  • right upper quadrant tenderness
  • fever
  • anorexia
  • nausea/vomiting
  • arthralgia/arthritis
  • abdominal pain
  • diarrhea
  • neurologic manifestations
  • signs of coagulopathy
Detalhes completos

Fatores de risco

  • born or living in or travel to geographic regions where HEV is endemic
  • immunosuppression
  • infected mother (for fetus)
  • person-to-person transmission
  • occupational exposure
  • blood/blood products transfusion
  • organ transplantation (if organ donor is HEV-positive)
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • serum antibody to HEV
  • HEV RNA nucleic acid amplification techniques (NAATs)
  • serologic tests for other causes of viral hepatitis
  • liver biochemistries
  • CBC
  • basic metabolic panel
  • coagulation profile
Detalhes completos

Investigações a serem consideradas

  • abdominal ultrasound
  • CT/MRI
  • liver biopsy
Detalhes completos

Algoritmo de tratamento

AGUDA

acute HEV infection

CONTÍNUA

chronic HEV infection: nonpregnant

chronic HEV infection: pregnant

Colaboradores

Autores

Jawad Ahmad, MD, FRCP, FAASLD

Professor of Medicine

Division of Liver Diseases

Mount Sinai Hospital

New York

NY

Declarações

JA declares that he has no competing interests.

Revisores

Scott J. Cotler, MD

Professor of Medicine

Director, Division of Hepatology

Loyola University Medical Center

Maywood

IL

Declarações

SJC declares that he has no competing interests.

David John Mutimer, MBBS, MD

Professor of Clinical Hepatology

University of Birmingham

Birmingham

UK

Declarações

DJM declares that he has no competing interests.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Centers for Disease Control and Prevention. Viral hepatitis: hepatitis E. Jun 2020 [internet publication].Texto completo

European Association for the Study of the Liver. EASL clinical practice guidelines on hepatitis E virus infection. J Hepatol. 2018 Jun;68(6):1256-71.Texto completo  Resumo

Public Health England. ​Hepatitis E: symptoms, transmission, treatment and prevention. May 2020 [internet publication].Texto completo

Miller JM, Binnicker MJ, Campbell S, et al; Infectious Diseases Society of America and the American Society for Microbiology. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis. 2018 Aug 31;67(6):e1-94.Texto completo  Resumo

Artigos de referência

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