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Cardiac arrest

Last reviewed: 10 Dec 2025
Last updated: 16 Dec 2025

Summary

Definition

History and exam

Key diagnostic factors

  • patient unresponsive
  • absence of normal breathing
  • absence of circulation
  • cardiac rhythm disturbance
Full details

Risk factors

  • coronary artery disease (CAD)
  • left ventricular dysfunction
  • age
  • hypertrophic cardiomyopathy (HCM)
  • arrhythmogenic right ventricular dysplasia (ARVD)
  • long QT syndrome (LQTS)
  • medications that prolong the QT interval or cause electrolyte disturbances
  • acute medical or surgical emergency
  • poisoning
  • Brugada syndrome
  • valvular heart disease
  • smoking
  • history of eating disorders
Full details

Diagnostic tests

1st tests to order

  • continuous cardiac monitoring
  • CBC
  • serum electrolytes
  • ABG
  • cardiac biomarkers
  • point of care ultrasound (POCUS)
Full details

Tests to consider

  • ECG
  • coronary angiography
  • echocardiogram
  • exercise stress testing
  • chest x-ray
  • toxicology screen
  • cardiac magnetic resonance imaging
  • coronary computed tomography angiography
  • signal-averaged ECG (SAECG)
  • electrophysiologic study
Full details

Treatment algorithm

INITIAL

unwitnessed cardiac arrest

ACUTE

shockable rhythms (pulseless ventricular tachycardia or ventricular fibrillation)

nonshockable rhythms (pulseless electrical activity or asystole)

ONGOING

return of spontaneous circulation

no return of spontaneous circulation

Contributors

Authors

John Wink, MD

Emergency Physician

Alberta Health Services

Alberta

Canada

Disclosures

JW declares that he has no competing interests.

Eddy Lang, MD

Professor and Department Head of Emergency Medicine

Cumming School of Medicine

University of Calgary

Alberta Health Services

Calgary

Canada

Disclosures

EL declares that he has no competing interests.

Acknowledgements

Dr John Wink and Professor Eddy Lang would like to gratefully acknowledge Dr Amar Krishnaswamy and Dr Arman T. Askari, previous contributors to this topic.

Disclosures

AK and ATA declare that they have no competing interests.

Peer reviewers

Vaikom Mahadevan, MD

Professor of Medicine

Division of Cardiology

University of California

San Francisco

CA

Disclosures

VM declares that he has no competing interests.

Anthony Aizer, MD, MS

Instructor

NYU Department of Medicine (Cardiology)

Leon H Charney Heart Rhythm Center and New York University

New York

NY

Declarações

AA declares that he has no competing interests.

Massimo F. Piepoli, MD, PhD, FESC

Honorary Clinical Senior Lecturer/Consultant

Department of Cardiology

Imperial College London

London

UK

Declarações

MFP declares that he has no competing interests.

Créditos aos pareceristas

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Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

Panchal AR, Bartos JA, Cabañas JG, et al. Part 3: adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2020 Oct 20;142(16_suppl_2):S366-468.Texto completo  Resumo

Martin SS, Aday AW, Allen NB, et al. 2025 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation. 2025 Feb 25;151(8):e41-660.Texto completo  Resumo

Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2022 Oct 21;43(40):3997-4126.Texto completo  Resumo

Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Circulation. 2018 Sep 25;138(13):e272-391.Texto completo  Resumo

Greif R, Bray JE, Djärv T, et al. 2024 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations: summary from the basic life support; advanced life support; pediatric life support; neonatal life support; education, implementation, and teams; and first aid task forces. Resuscitation. 2024 Dec;205:110414.Texto completo  Resumo

Nolan JP, Sandroni C, Böttiger BW, et al. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care. Intensive Care Med. 2021 Apr;47(4):369-421.Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
  • Cardiac arrest images
  • Diretrizes

    • Critical care management of patients after cardiac arrest: a scientific statement from the American Heart Association and Neurocritical Care Society
    • 2024 International consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations
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