Cervical cancer is a human papillomavirus (HPV)-related malignancy, preventable by HPV vaccination, screening, and treatment of high-grade dysplasia.
Cervical cancer screening by cytology (Pap testing) alone, Pap and HPV co-testing, or primary HPV testing may detect pre-invasive disease.
Patients are commonly asymptomatic at presentation, and identified following screening. Patients with advanced disease may present with symptoms such as abnormal vaginal bleeding, postcoital bleeding, vaginal discharge, pelvic or back pain, dyspareunia, or obstructive uropathy.
Staging using International Federation of Gynecology and Obstetrics criteria is based on clinical assessment only. When available, advanced imaging modalities (magnetic resonance imaging, positron emission tomography [PET], PET/computed tomography [CT], CT) are used to evaluate the local extent of disease and to screen for metastases, which may guide treatment planning.
For microinvasive disease, treatment with conization or simple (extrafascial) hysterectomy is recommended.
For early stage invasive disease, surgery is recommended.
For locally advanced disease, chemoradiation therapy is significantly superior to radiation therapy alone.
Cervical cancer is a human papillomavirus-related malignancy of the uterine cervical mucosa.
History and exam
Key diagnostic factors
- abnormal vaginal bleeding
- postcoital bleeding
- pelvic or back pain
- cervical mass
- cervical bleeding
Other diagnostic factors
- mucoid or purulent vaginal discharge
- bladder, renal, or bowel obstruction
- bone pain
- human papillomavirus (HPV) infection
- age group
- HIV infection
- early onset of sexual activity (younger than 18)
- multiple sexual partners
- cigarette smoking
- history of STI
- oral contraceptive pill use
- high parity
- uncircumcised male partner
- micronutrient malnutrition
- low serum folate
- low vitamin C and E levels
- alcohol use
- low socioeconomic status
1st investigations to order
- vaginal or speculum examination
- human papillomavirus (HPV) testing
Investigations to consider
- renal function testing
- liver function tests
- chest x-ray
- intravenous pyelogram
- renal ultrasound
- barium enema
- MRI pelvis
- PET whole body
- PET/CT whole body
- CT of chest/abdomen/pelvis with intravenous/oral contrast
- p16 and Ki67 biomarker expression
nonpregnant stage IA1: microinvasive disease
nonpregnant stage IA2 or IB1: early stage disease
nonpregnant stage IB2-IIA: early stage disease
nonpregnant stage IIB-IVA: locally advanced disease
nonpregnant stage IVB: metastatic disease
nonpregnant: local or regional recurrent disease
pregnant: any stage
- Human papillomavirus (HPV) infection
- Pelvic infection
- Nabothian cyst
- WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition: use of mRNA tests for human papillomavirus (HPV)
- Guidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV
HPV (human papillomavirus) vaccineMore Patient leaflets
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