Acute febrile illness lasting 5 or more days.
Typical signs include fever, polymorphic rash, injected eyes, and mucosal erythema with strawberry tongue.
Swelling and erythema of the hands and feet occur in the acute stage, followed by desquamation in the second week.
Unilateral nonpurulent cervical lymphadenopathy is present in about 40% of cases.
Coronary aneurysms develop in 20% to 25% of untreated patients.
Standard treatment includes intravenous immune globulin and/or aspirin. In resistant cases, corticosteroids or a tumor necrosis factor (TNF)-alpha inhibitor may be necessary.
Kawasaki disease (KD) is an acute, febrile, self-limiting, systemic vasculitis of unknown origin that almost exclusively affects young children. In an immunogenetically predisposed host, one or more infectious agents may play a role in triggering the clinical manifestations of the disease. Clinically, it is characterized by fever, polymorphic rash, conjunctivitis, mucosal erythema with strawberry tongue, induration of the hands and feet, and unilateral cervical lymphadenopathy. Morbidity and mortality depend on coronary aneurysms that develop in 20% to 25% of untreated patients. KD is the leading cause of acquired heart disease in children under 5 years of age in the US and other developed countries.
History and exam
Professor of Pediatrics and Chief
Division of Pediatric Rheumatology
LSU Health Sciences Center and Children's Hospital
AG declares that he has no competing interests.
Assistant Professor of Clinical Pediatrics
Department of Pediatric Cardiology
JK declares that he is a paid consultant for Axia Medical Solutions, a small skincare company from Carlsbad, CA.
Professor of International Child Health
Imperial College London
ML declares that he has no competing interests
Editor in Chief
Journal of Clinical Pediatrics
Department of Pediatrics
Division of Infectious Diseases
Ochsner Children's Health Center
RWS declares that he has no competing interests.
Clinical Professor of Pediatrics
Department of Pediatrics
Oregon Health Science University
JLE declares that he has no competing interests.
Principal Research Fellow
Murdoch Childrens Research Institute
The Royal Children’s Hospital
DB has received competitive research funding from the National Heart Foundation Australia and from the Agency for Science, Technology and Research of the Singapore Government. He is co-inventor on a patent related to diagnostics submitted through the Genome Institute of Singapore.
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