Allergic rhinitis is an immunoglobulin E (IgE)-mediated inflammatory nasal condition resulting from allergen introduction in a sensitized individual.
Presumptive diagnosis of allergic rhinitis is usually clinical and is made if someone experiences one or more of rhinorrhea, sneezing, itching of nose/palate/eyes, or nasal congestion in response to allergen exposure. Cough is also a common symptom.
The diagnosis is confirmed with demonstration of specific IgE reactive to environmental allergens. Food allergy testing is not recommended in the routine evaluation of rhinitis.
Treatment includes allergen avoidance (reducing exposure to relevant allergens such as dander, dust mite, and pollen), pharmacotherapy, and immunotherapy.
Intranasal corticosteroids remain the single most effective class of medications for treating allergic rhinitis.
Immunotherapy is often recommended for patients with persistent symptoms.
Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory nasal condition resulting from allergen exposure in a sensitized individual. AR is a common inflammatory condition of the upper respiratory tract, characterized by nasal pruritus, sneezing, rhinorrhea, and nasal congestion. Frequently, there is associated palate, throat, ear, and eye itching as well as eye redness, puffiness, and watery discharge.
AR may sometimes be due to occupational or hobby exposures to proteins that do not commonly provoke IgE-mediated responses. Examples include woodworkers becoming sensitized to wood dusts, or food service workers becoming sensitized to grain dusts.
History and exam
Key diagnostic factors
- nasal pruritus
Other diagnostic factors
- palate, throat, ear, and eye itching
- eye redness, puffiness, and watery discharge
- fatigue and irritability
- nasal congestion
- allergic shiners
- conjunctival injection
- ocular mucoid discharge
- nasal crease
- pale nasal mucosa
- swelling of the nasal mucosa and turbinates
- abundant clear nasal secretions
- Dennie-Morgan lines (creases present under the lower eyelids)
- other atopic conditions or family history of atopy
- age <20 years
- exposure to aeroallergens (pollen, molds, house dust mites, pollution)
- exposure to animal dander
- positive allergen skin-prick tests
1st investigations to order
- therapeutic trial of antihistamine or intranasal corticosteroid
Investigations to consider
- allergen skin-prick testing
- in vitro specific IgE determination
mild or intermittent symptoms
persistent and moderate to severe symptoms
usual therapy ineffective or poorly tolerated
- Nonallergic rhinitis
- Acute sinusitis
- Chronic sinusitis
- Japanese guidelines for allergic rhinitis 2020
- Next-generation Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence
Hay fever: avoiding pollen and moldMore Patient leaflets
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