Also known as pattern hair loss, androgenetic alopecia is a genetically determined, patterned, progressive loss of hair from the scalp and occurs in both men and women. Both androgens and genetics play a role in its pathogenesis.
The term androgenetic alopecia is best used only when referring to male-pattern hair loss, as most females likely do not share the androgenic pathway. A more appropriate term for women is female-pattern hair loss. The term pattern hair loss will be used when referring to hair loss affecting both sexes.
Men present with hair thinning in the temporal areas that advances to the crown (vertex) area as the alopecia progresses. Women usually have more diffuse thinning on the crown area, and less commonly present with a male-type pattern.
Diagnosis is clinical and is based on recognizing the pattern of hair loss.
Possible treatments are oral finasteride and/or topical minoxidil solution or foam for men, and topical minoxidil solution or foam for women.
For women with female-pattern hair loss and concomitant hyperandrogenism (<40% of cases), additional androgen-suppressive therapy may be considered.
A genetically determined, patterned, progressive loss of hair from the scalp. In men, hair loss is caused by androgen-mediated follicular miniaturization that leads to fine, short, nonpigmented, vellus hair formation. The pathogenesis of female-pattern hair loss has not been well characterized, and androgens are not believed to play a major role for most women. Historically, the incidence of male- and female-pattern hair loss has been significantly underestimated by the exclusion of the early stages of hair loss. If all stages of hair loss are included, the incidence of pattern hair loss may be as high as 98% in men, and 86% in women. Men present with gradual thinning in the temporal areas, producing a characteristic M shape with gradual extension to the crown (vertex) area. Women usually present with diffuse thinning on the crown area while maintaining a frontal hairline.
History and exam
Carolyn Goh, MD
Associate Clinical Professor
Department of Medicine
Division of Dermatology
UCLA Medical Center
CG has spoken for the International Society of Hair Restoration Surgeons, the American Academy of Dermatology, the Pacific Dermatologic Association, and has had manuscripts published in a variety of journals.
Dr Carolyn Goh would like to gratefully acknowledge Dr Robert Haber, Dr Christiane Querfeld, and Dr Christopher R. Shea, previous contributors to this topic. RH has an ownership interest in a company that manufactures light-based hair growth devices and receives royalties for the sales of a surgical device used in hair restoration surgery. CQ and CRS declare that they have no competing interests.
Marcelo G. Horenstein, MD
Director of Dermatopathology
The Dermatology Group
MGH declares that he has no competing interests.
Alvin R. Solomon, MD
Professor of Dermatology
Emory University School of Medicine
ARS declares that he has no competing interests.
David Whiting, MD, FACP
The Baylor Hair and Skin Research and Treatment Center
DW is an author of a number of references cited in this topic. We have since been made aware that Dr David Whiting is deceased.
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