Prevention includes appropriate management of tetanus-prone wounds and complete active immunization, with passive immunization administered when required.
Diagnosis is based on clinical findings that include trismus, muscle rigidity, spasms, respiratory embarrassment, dysphagia, or autonomic dysfunction.
Management of clinical tetanus includes supportive care, wound debridement, antimicrobials, passive and active immunization, control of muscle spasms, and management of autonomic dysfunction.
Tetanus is a life-threatening neurologic syndrome characterized by tonic muscle spasms and hyperreflexia, caused by the exotoxin of Clostridium tetani, a gram-positive spore-forming obligate anaerobe.
Consultant in Infectious Diseases
Leeds Teaching Hospitals NHS Trust
LEC declares that she has no competing interests.
Senior Lecturer (Honorary Consultant)
Liverpool School of Tropical Medicine and Royal Liverpool University Hospital
NJB is an author of several references cited in this monograph. NJB is partially supported by the National Institute of Health Research Health Protection Unit in Emerging and Zoonotic Infections at the University of Liverpool and Public Health England. He is affiliated with the Liverpool School of Tropical Medicine. Views expressed in this monograph are those of the contributor and do not necessarily represent the official position of the National Health Service, the National Institute for Health Research, the Department of Health, or Public Health England.
Professor in Paediatric Infection (Honorary Consultant)
University of Liverpool and Alder Hey Children’s NHS Foundation Trust
EDC declares that she has no competing interests.
Consultant in Medical Microbiology
Alder Hey Children’s NHS Foundation Trust
Honorary Senior Lecturer, University of Liverpool
Honorary Clinical Research Fellow, Liverpool School of Tropical Medicine
School of Tropical Medicine and Global Health
CMP is an author of a number of references cited in this monograph.
Senior Clinical Research Fellow
Oxford University Clinical Research Unit
Hospital for Tropical Diseases
Ho Chi Minh City
Centre for Tropical Medicine and Global Health
LT is an author of a number of references cited in this monograph.
U.S. Public Health Service
HIV Vaccine Team
Division of HIV/AIDS Prevention
National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
Centers for Disease Control and Prevention
KK declares that she has no competing interests.
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