Summary
Definition
History and exam
Key diagnostic factors
- obesity
- male sex
- maxillomandibular anomalies
- excessive daytime sleepiness
- episodes of apnoea
- episodic gasping
- restless sleep
- insomnia
- macroglossia
- chronic snoring
Other diagnostic factors
- cardiovascular disease
- weight gain
- large neck circumference
- endocrine disorders
- history of difficult intubation for general anaesthesia; obstruction during sedation
- family history of OSA or snoring
- history of mucopolysaccharidoses
- history of GORD
- history of Down's syndrome
- history of tooth extractions for crowding
- history of motor vehicle accidents
- neurocognitive dysfunction
- mood disorders
- nocturia
- erectile dysfunction
- morning headaches
- heartburn/dyspepsia
- dry mouth
- nocturnal sweating
Risk factors
- obesity
- male sex
- post-menopause (women)
- large neck circumference
- maxillomandibular anomalies (e.g., narrowing, retrognathia, and high, arched palate)
- increased volume of soft tissues (includes tonsils, adenoids, and tongue)
- family history of OSA
- chronic snoring
- polycystic ovary syndrome (PCOS)
- hypothyroidism
- Down's syndrome
- mucopolysaccharidoses
- increasing age
- black, Hispanic, or Asian ethnicity
- tobacco smoking
- nasal obstruction
- levels of sex hormones
- alcohol use
- environmental tobacco smoke exposure
- opioid use
Diagnostic investigations
1st investigations to order
- attended polysomnography (PSG)
- unattended non-laboratory PSG
- portable multichannel home sleep tests
- awake fibreoptic endoscopy
Emerging tests
- dynamic MRI
- drug-induced sleep endoscopy (DISE)
- machine learning
Treatment algorithm
Apnoea-Hypopnoea Index (AHI) or Respiratory Event Index (REI) of ≥30 episodes/hour: no discrete anatomical lesions
AHI or REI of ≥5 but <30 episodes/hour: no discrete anatomical lesions
AHI or REI of ≥5 episodes/hour with discrete anatomical lesions
persistent post-operative OSA
Contributors
Authors
Ofer Jacobowitz, MD, PhD, FAASM
Co-director of Sleep
ENT and Allergy Associates
Associate Professor
Department of Otolaryngology
Northwell/Zucker School of Medicine, Hofstra University
New York
NY
Disclosures
OJ is a scientific consultant for, and has received a consulting fee from Aerin Medical, LivaNova, Deerfield Catalyst, and Nyxoah. OJ has received research support from LivaNova for US Food and Drug Administration trial research. Aerin Medical has developed nasal valve treatment devices for nasal obstruction. Both LivaNova and Nyxoah have developed implantable neurostimulation systems for obstructive sleep apnoea. Zsquare has developed endoscopy systems. OJ is an author of a paper cited in this topic.
Peer reviewers
Carla Daltro, MD
Professor of Medicine
Bahiana School of Medicine and Public Health
Brazil
Disclosures
CD has been reimbursed by Sanofi-Aventis, Novartis, Merck Sharp Dohme, and Eli Lilly as an investigator of clinical trials.
Krishna M. Sundar, MD
Adjunct Assistant Professor
University of Utah
Director
Pulmonary & Critical Care Research
IHC Urban South Intermountain Utah Valley Pulmonary Clinic
Provo
UT
Disclosures
KMS declares that he has no competing interests.
Differentials
- Central sleep apnoea and Cheyne-Stokes respiration (CSB)
- Narcolepsy
- Insufficient sleep
More DifferentialsGuidelines
- International classification of sleep disorders, 3rd edition, text revision (ICSD-3-TR)
- Sleep-disordered breathing and cardiac arrhythmias in adults: mechanistic insights and clinical implications: a scientific statement
More GuidelinesPatient information
Sleep apnoea in adults (obstructive)
More Patient informationCalculators
Epworth Sleepiness Scale (ESS)
More Calculators- Log in or subscribe to access all of BMJ Best Practice
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