Obstructive sleep apnea in adults

Last reviewed: 29 Aug 2022
Last updated: 15 Oct 2020

Summary

Definition

History and exam

Key diagnostic factors

  • obesity
  • male sex
  • maxillomandibular anomalies
  • excessive daytime sleepiness
  • episodes of apnea
  • episodic gasping
  • restless sleep
  • insomnia
  • macroglossia
  • chronic snoring
More key diagnostic factors

Other diagnostic factors

  • cardiovascular disease
  • weight gain
  • large neck circumference
  • endocrine disorders
  • history of difficult intubation for general anesthesia
  • family history of OSA or snoring
  • history of mucopolysaccharidoses
  • history of GERD
  • history of Down syndrome
  • history of tooth extractions for crowding
  • history of motor vehicle accidents
  • neurocognitive dysfunction
  • mood disorders
  • nocturia
  • erectile dysfunction
  • morning headaches
  • heartburn/dyspepsia
  • dry mouth
  • nocturnal sweating
Other diagnostic factors

Risk factors

  • obesity
  • male sex
  • postmenopause (women)
  • large neck circumference
  • maxillomandibular anomalies (e.g., narrowing, retrognathia, and high, arched palate)
  • increased volume of soft tissues (includes tonsils, adenoids, and tongue)
  • family history of OSA
  • chronic snoring
  • nasal obstruction
  • polycystic ovary syndrome
  • levels of sex hormones
  • hypothyroidism
  • Down syndrome
  • mucopolysaccharidoses
  • alcohol use
  • increasing age
  • black, Hispanic, or Asian ethnicity
  • tobacco smoking
More risk factors

Diagnostic investigations

1st investigations to order

  • polysomnography (PSG)
  • portable multichannel sleep tests
  • awake fiberoptic endoscopy
More 1st investigations to order

Emerging tests

  • cine MRI
  • drug-induced sleep endoscopy (DISE)
  • cardiovascular and neurological tests
  • biochemical or genetic signatures and assays

Treatment algorithm

ACUTE

Apnea-Hypopnea Index (AHI) or Respiratory Event Index (REI) of ≥30 episodes/hour: no discrete anatomic lesions

AHI or REI of ≥5 but <30 episodes/hour: no discrete anatomic lesions

AHI or REI of ≥5 episodes/hour with discrete anatomic lesions

ONGOING

persistent postoperative OSA

Contributors

Authors

Ofer Jacobowitz, MD, PhD, FAASM

Co-director of Sleep

ENT and Allergy Associates

Associate Professor

Department of Otolaryngology

Northwell/Zucker School of Medicine, Hofstra University

New York

NY

Disclosures

OJ is a scientific consultant for, and has received a consulting fee from, LivaNova and Nyxoah. OJ has received research support from LivaNova for Food and Drug Administration trial research. Both LivaNova and Nyxoah have developed implantable neurostimulation systems for obstructive sleep apnea.

Peer reviewers

Carla Daltro, MD

Professor of Medicine

Bahiana School of Medicine and Public Health

Brazil

Disclosures

CD has been reimbursed by Sanofi-Aventis, Novartis, Merck Sharp Dohme, and Eli Lilly as an investigator of clinical trials.

Krishna M. Sundar, MD

Adjunct Assistant Professor

University of Utah

Director

Pulmonary & Critical Care Research

IHC Urban South Intermountain Utah Valley Pulmonary Clinic

Provo

UT

Disclosures

KMS declares that he has no competing interests.

  • Differentials

    • Central sleep apnea and Cheyne-Stokes respiration (CSB)
    • Narcolepsy
    • Insufficient sleep
    More Differentials
  • Guidelines

    • VA/DoD clinical practice guideline for the management of chronic insomnia disorder and obstructive sleep apnea
    • Treatment of adult obstructive sleep apnea with positive airway pressure
    More Guidelines
  • Patient leaflets

    Sleep apnea in adults (obstructive)

    More Patient leaflets
  • Calculators

    Epworth Sleepiness Scale (ESS)

    More Calculators
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