Summary
Definition
History and exam
Key diagnostic factors
- obesity
- male sex
- maxillomandibular anomalies
- excessive daytime sleepiness
- episodes of apnea
- episodic gasping
- restless sleep
- insomnia
- macroglossia
- chronic snoring
Other diagnostic factors
- cardiovascular disease
- weight gain
- large neck circumference
- endocrine disorders
- history of difficult intubation for general anesthesia; obstruction during sedation
- family history of OSA or snoring
- history of mucopolysaccharidoses
- history of GERD
- history of Down syndrome
- history of tooth extractions for crowding
- history of motor vehicle accidents
- neurocognitive dysfunction
- mood disorders
- nocturia
- erectile dysfunction
- morning headaches
- heartburn/dyspepsia
- dry mouth
- nocturnal sweating
Risk factors
- obesity
- male sex
- postmenopause (women)
- large neck circumference
- maxillomandibular anomalies (e.g., narrowing, retrognathia, and high, arched palate)
- increased volume of soft tissues (includes tonsils, adenoids, and tongue)
- family history of OSA
- chronic snoring
- polycystic ovary syndrome (PCOS)
- hypothyroidism
- Down syndrome
- mucopolysaccharidoses
- increasing age
- black, Hispanic, or Asian ethnicity
- tobacco smoking
- nasal obstruction
- levels of sex hormones
- alcohol use
- environmental tobacco smoke exposure
- opioid use
Diagnostic tests
1st tests to order
- attended polysomnography (PSG)
- unattended nonlaboratory PSG
- portable multichannel home sleep tests
- awake fiberoptic endoscopy
Emerging tests
- dynamic MRI
- drug-induced sleep endoscopy (DISE)
- machine learning
Treatment algorithm
Apnea-Hypopnea Index (AHI) or Respiratory Event Index (REI) of ≥30 episodes/hour: no discrete anatomic lesions
AHI or REI of ≥5 but <30 episodes/hour: no discrete anatomic lesions
AHI or REI of ≥5 episodes/hour with discrete anatomic lesions
persistent postoperative OSA
Contributors
Authors
Ofer Jacobowitz, MD, PhD, FAASM
Co-director of Sleep
ENT and Allergy Associates
Associate Professor
Department of Otolaryngology
Northwell/Zucker School of Medicine, Hofstra University
New York
NY
Disclosures
OJ is a scientific consultant for, and has received a consulting fee from Aerin Medical, LivaNova, Deerfield Catalyst, and Nyxoah. OJ has received research support from LivaNova for Food and Drug Administration trial research. Aerin Medical has developed nasal valve treatment devices for nasal obstruction. Both LivaNova and Nyxoah have developed implantable neurostimulation systems for obstructive sleep apnea. Zsquare has developed endoscopy systems. OJ is an author of a paper cited in this topic.
Peer reviewers
Carla Daltro, MD
Professor of Medicine
Bahiana School of Medicine and Public Health
Brazil
Disclosures
CD has been reimbursed by Sanofi-Aventis, Novartis, Merck Sharp Dohme, and Eli Lilly as an investigator of clinical trials.
Krishna M. Sundar, MD
Adjunct Assistant Professor
University of Utah
Director
Pulmonary & Critical Care Research
IHC Urban South Intermountain Utah Valley Pulmonary Clinic
Provo
UT
Disclosures
KMS declares that he has no competing interests.
Differentials
- Central sleep apnea and Cheyne-Stokes respiration (CSB)
- Narcolepsy
- Insufficient sleep
More DifferentialsGuidelines
- International classification of sleep disorders, 3rd edition, text revision (ICSD-3-TR)
- Sleep-disordered breathing and cardiac arrhythmias in adults: mechanistic insights and clinical implications: a scientific statement
More GuidelinesPatient information
Sleep apnea in adults (obstructive)
More Patient informationCalculators
Epworth Sleepiness Scale (ESS)
More Calculators- Log in or subscribe to access all of BMJ Best Practice
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