Last reviewed: February 2020
Last updated: January  2018



History and exam

Key diagnostic factors

  • nausea
  • vomiting
  • diarrhea
  • abdominal pain

Other diagnostic factors

  • malaise
  • anorexia
  • fever
  • volume depletion

Risk factors

  • exposure to contaminated food or water sources
  • close contact with infected people
  • poor hygiene
  • extreme ages
  • HIV infection
  • organ transplantation
  • chronic illness

Diagnostic investigations

Investigations to consider

  • basic metabolic profile (BMP)
  • renal function
  • stool rapid antigen testing
  • stool reverse transcriptase PCR (RT-PCR) or multiplex PCR
  • stool viral culture
  • stool electron microscopy
  • stool for culture, ova, and parasites
More investigations to consider

Treatment algorithm


Associate Professor of Internal Medicine

University of Iowa Carver College of Medicine

Iowa City



KEB declares that she has no competing interests.

Dr Kyle E. Brown would like to gratefully acknowledge Dr Easwaran Variyam, Dr Robert Schiller, Dr Srikrishna Nagri, and Dr Sury Anand, the previous contributors to this topic. EV, RS, SN, and SA declare that they have no competing interests.

Peer reviewersVIEW ALL

Department of Infectious Diseases

Universidade Federal de São Paulo

São Paulo



ARM declares that he has no competing interests.

Infectious Disease Specialist

Alabama Infectious Diseases Center




AH declares that he has no competing interests.

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