Episodic cocaine use leads to short-lived states of autonomic arousal. Chronic use can lead to scarring of heart tissue and myocardial hypertrophy and other changes collectively known as myocardial remodeling. These changes constitute the substrate for the occurrence of lethal arrhythmias.
Cocaine binds to the hERG (rapid repolarizing potassium) channel, disrupting the normal process of depolarization in heart muscle. Cocaine should not, therefore, be used concomitantly with drugs known to cause QT interval prolongation
While chest pain related to cocaine use is a common reason for seeking medical care, occasional use is rarely associated with acute myocardial infarction (AMI) unless there is pre-existing coronary artery disease.
Psychosis can be seen in chronic users as an isolated condition or as a feature of "excited delirium". It is an agitated confusional state associated with potentially lethal hyperthermia.
There is no evidence to support the use of antipsychotic agents for cocaine dependence. Antipsychotic agents may cause QT interval prolongation and, when used concomitantly with cocaine, may compound the risk of sudden death.
Cocaine is a drug of abuse that is usually either insufflated (snorted), injected, or smoked in its freebase form (crack). Cocaine is a type IA antidysrhythmic, local anesthetic, and sympathomimetic. It can also bind the hERG (slowly depolarizing inward potassium channel), which is prodysrhythmic.
Consultant Cardiac Pathologist/Toxicologist (ret.)
Office of the Chief Medical Examiner
SBK is an author of a number of references cited in this monograph. SBK declares that he has no other competing interests.
Division of Pulmonary and Critical Care Medicine
University of California, Davis
TA declares that he has no competing interests.
Department of Emergency Medicine
Johns Hopkins University Hospital
AS declares that he has no competing interests.
Assistant Professor of Community Health and Associate Director
Center for Interventions
Treatment and Addictions Research
Wright State University Boonshoft School of Medicine
RF declares that he has no competing interests.
Consultant Psychiatrist and Honorary Senior Lecturer
Addictions, Alcohol Research
Institute of Psychiatry
King's College London
CK declares that he has no competing interests.
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