Syndrome of inappropriate antidiuretic hormone (SIADH) is defined as euvolemic, hypotonic hyponatremia secondary to impaired free water excretion, usually from excessive arginine vasopressin (AVP) release.
Severe neurologic symptoms, such as altered mental status, seizure, and coma, may result from SIADH and these are always treated with hypertonic saline, with close monitoring to avoid overcorrection of serum sodium.
Central pontine myelinolysis (osmotic demyelination syndrome) may occur with rapid correction of serum sodium in excess of 12 mEq/L/day.
Vasopressin receptor antagonists (also known as vaptans) are a class of medications that compete with the antidiuretic hormone AVP for binding at the vasopressin receptor, permitting free water excretion.
The syndrome of inappropriate antidiuretic hormone (SIADH) is characterized by hypotonic hyponatremia, concentrated urine, and a euvolemic state. The impairment of free water excretion is caused by increased arginine vasopressin (antidiuretic hormone or AVP) release. Pseudohyponatremia due to hyperglycemia, hyperlipidemia, or hyperproteinemia should be ruled out first. Renal failure, adrenal insufficiency, and appropriate release of AVP secondary to extracellular volume depletion (hypovolemia, due to gastrointestinal or renal loss) or intravascular volume depletion (hypervolemia due to congestive heart failure, cirrhosis of the liver, or nephrotic syndrome) must be ruled out in order to diagnose SIADH.
History and exam
Megan Dixon, MD
Arizona Kidney Disease and Hypertension Center
MD declares that she has no competing interests.
Howard Lien, MD, PhD
Professor Emeritus of Medicine
Division of Nephrology
University of Arizona
HL is an author of a reference cited in this topic.
Judith H. Veis, MD
Washington Hospital Center
JHV declares that she has no competing interests.
Laurie Solomon, MD, FRCP
Lancashire Teaching Hospitals
LS declares that he has no competing interests.
Use of this content is subject to our disclaimer