Menopause

The diagnosis of menopause is clinical, based on the absence of menses for 12 months, and does not require further testing for appropriately presenting patients.

Estrogen therapy is an effective treatment for the management of menopausal symptoms including hot flashes, night sweats, and urogenital symptoms.

For women with an intact uterus, a progestin must be co-administered with an estrogen to protect against endometrial hyperplasia and cancer.

Arbitrary limits should not be placed on the duration of use of hormone therapy (HT); all patients require individualized decision-making. Reassessment should occur at least annually. Transdermal administration of estradiol is associated with a lower risk of stroke and venous thromboembolism than oral administration of estradiol and is unlikely to increase the risk of stroke and venous thrombosis above that of non-users.

Nonhormonal interventions may help women who have a contraindication to, or cannot tolerate, HT. However, they are less effective than HT in controlling menopausal symptoms.

Onset of menopause is heralded by the cessation of menses for at least 12 consecutive months, without some other reason for amenorrhea (such as pregnancy, hormone therapy, or other medical condition). No further testing is indicated for amenorrhea in an appropriate clinical context or symptoms of menopause in a woman without a uterus.​[1]National Institute for Health and Care Excellence. Menopause: identification and management. Apr 2026 [internet publication]. https://www.nice.org.uk/guidance/ng23

Permanent cessation of ovarian function may occur surgically by removal of both ovaries (surgical menopause) or medically, usually due to chemotherapy or radiation therapy (treatment-induced menopause).

The perimenopause includes the years before and after the cessation of menses in an ovulating woman and is marked by irregular menses and menopausal symptoms. Management of menopause symptoms requires individualization based on each woman’s clinical circumstance.