Last reviewed: 30 Oct 2020
Last updated: 27 Oct 2020

Summary

Definition

History and exam

Key diagnostic factors

  • chronic pain
  • diffuse tenderness on examination

Other diagnostic factors

  • fatigue unrelieved by rest
  • sleep disturbance
  • mood disturbance
  • cognitive dysfunction
  • headaches
  • numbness/tingling sensations
  • stiffness
  • sensitivity to sensory stimuli such as bright lights, odors, noises

Risk factors

  • family history of fibromyalgia
  • rheumatologic conditions
  • age between 20 and 60 years
  • female sex
  • presence of associated conditions

Diagnostic investigations

Investigations to consider

  • erythrocyte sedimentation rate/CRP
  • thyroid function test
  • CBC
  • rheumatoid factor
  • anti-cyclic citrullinated protein (CCP) antibody
  • antinuclear antibody
  • vitamin D level
More investigations to consider

Treatment algorithm

Contributors

Professor of Anesthesiology, Medicine, and Psychiatry

University of Michigan Health System

Ann Arbor

MI

Disclosures

DJC has received consulting fees from Pfizer, Eli Lilly, Nuvo, Cerephex, Tonix, Abbott, Forest Laboratories, Johnson & Johnson, Merck, Purdue Pharma, Zynerba, Astellas Pharmaceuticals, Williams & Connolly LLP, and Aptinyx; he has received research grant support from Pfizer, Cypress Biosciences, Forest Laboratories, Merck, Novo, Cerephex, and Aptinyx. DJC is an author of a number of references cited in this topic.

Dr Daniel J. Clauw would like to gratefully acknowledge Dr Lisa Ware Corbin, a previous contributor to this topic.

Disclosures

LWC declares that she has no competing interests.

Peer reviewersVIEW ALL

Emeritus Professor of Medicine

Tufts University School of Medicine

Boston

MA

Disclosures

DG declares that he has no competing interests.

Professor of Medicine and Nursing Research

Oregon Health & Science University

Portland

OR

Disclosures

RB declares that he has no competing interests.

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