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Guillain-Barre syndrome

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  • Overview
  • Theory
  • Diagnosis
  • Management
  • Follow up
  • Resources
ბოლო მიმოხილვა: 13 Nov 2025
ბოლო განახლება: 10 Nov 2022

შეჯამება

განსაზღვრება

ანამნეზი და გასინჯვა

ძირითადი დიაგნოსტიკური ფაქტორები

  • muscle weakness
  • paresthesia
  • back/leg pain
  • respiratory distress
  • speech problems
  • areflexia/hyporeflexia
  • facial weakness
  • bulbar dysfunction causing oropharyngeal weakness
  • extraocular muscle weakness
  • facial droop
  • diplopia
  • dysarthria
  • dysphagia
  • dysautonomia
  • pupillary dysfunction
  • ophthalmoplegia
სრული ტექსტი

სხვა დიაგნოსტიკური ფაქტორები

  • ptosis
  • altered level of consciousness
  • ataxia
სრული ტექსტი

რისკფაქტორები

  • preceding viral illness
  • preceding bacterial infection
  • preceding mosquito-borne viral infections
  • hepatitis E infection
  • immunization
  • cancer and lymphoma
  • older age
  • HIV infection
  • COVID-19 infection
  • male
სრული ტექსტი

დიაგნოსტიკური კვლევები

1-ად შესაკვეთი გამოკვლევები

  • nerve conduction studies
  • lumbar puncture
  • LFTs
  • spirometry
სრული ტექსტი

გასათვალისწინებელი კვლევები

  • antiganglioside antibody
  • serology
  • stool culture
  • HIV antibodies
  • spinal MRI
  • Borrelia burgdorferi serology
  • cerebrospinal fluid (CSF) meningococcal polymerase chain reaction
  • CSF cytology
  • CSF angiotensin-converting enzyme
  • chest x-ray
  • CSF VDRL
  • CSF West Nile polymerase chain reaction
სრული ტექსტი

ახალი ტესტები

  • ultrasound imaging of peripheral nerves

მკურნალობის ალგორითმი

მწვავე

ambulatory within 2 weeks of onset or nonambulatory within 4 weeks of onset

კონტრიბუტორები

ავტორები

Saiju Jacob, MD, DPhil, MRCP (UK), FRCP (Lon)

Consultant Neurologist

Queen Elizabeth Neurosciences Centre

University Hospital Birmingham

Birmingham

UK

გაფრთხილება:

SJ has served as an international advisory board member for Alexion, Alnylam, ArgenX, Regeneron, Immunovant, and UCB pharmaceuticals. He is currently an expert panel member of the Myasthenia Gravis consortium for ArgenX, and has received speaker fees from Terumo BCT and Eisai.

მადლიერება

Dr Saiju Jacob would like to gratefully acknowledge Dr John B. Winer, Dr Michael T. Torbey, Dr Dhruvil J. Pandya, and Dr Prem A. Kandiah, previous contributors to this topic.

გაფრთხილება:

JBW, MTT, DJP, and PAK declare that they have no competing interests.

რეცენზენტები

Cigdem Akman, MD

Division of Pediatric Neurology

Columbia University College of Physicians and Surgeons

New York

NY

利益声明

CA declares that he has no competing interests.

Robert Hadden, FRCP, PhD

Consultant Neurologist

King's College Hospital

London

UK

利益声明

RH has been paid by Baxter Healthcare Ltd for membership of its neurology advisory board, and is a co-author of several studies referenced in this topic.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

参考文献

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

关键文献

Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. Lancet. 2016 Aug 13;388(10045):717-27.全文  摘要

Stowe J, Andrews N, Wise L, et al. Investigation of the temporal association of Guillain-Barré syndrome with influenza vaccine and influenzalike illness using the United Kingdom General Practice Research Database. Am J Epidemiol. 2009 Feb 1;169(3):382-8.全文  摘要

Hughes RA, Swan AV, van Doorn PA. Intravenous immunoglobulin for Guillain-Barré syndrome. Cochrane Database Syst Rev. 2014 Sep 19;(9):CD002063.全文  摘要

Lawn ND, Fletcher DD, Henderson RD, et al. Anticipating mechanical ventilation in Guillain-Barré syndrome. Arch Neurol. 2001 Jun;58(6):893-8.全文  摘要

Hughes RA, Brassington R, Gunn AA, et al. Corticosteroids for Guillain-Barré syndrome. Cochrane Database Syst Rev. 2016 Oct 24;(10):CD001446.全文  摘要

Walgaard C, Jacobs BC, Lingsma HF, et al. Second intravenous immunoglobulin dose in patients with Guillain-Barré syndrome with poor prognosis (SID-GBS): a double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2021 Apr;20(4):275-83. 摘要

参考文献

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.

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