In 2019, lower respiratory tract infections affected 489 million people worldwide, and were the cause for approximately 2.5 million deaths. Children <5 years old and adults >70 years old were the populations most affected by pneumonia. Mortality was highest in patients aged >70 years old. Lower respiratory tract infections were the leading cause of infectious disease mortality worldwide in 2019.
In the US, the annual incidence of CAP has been estimated at 24.8 cases in 10,000 adults. Pneumonia and influenza, when considered together, were the eighth leading cause of death (13.5 deaths in 100,000 population) and the leading infectious cause in the US in 2016. In the US, the annual rate of hospitalization for adults ≥65 years old ranges from 847 to 3500 per 100,000 persons; the rate is lower for adults <65 years old (89 to 1138 per 100,000 persons).
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