The global burden of diseases, injuries, and risk factors (GDB) study showed that lower respiratory tract infections affected over 336 million people all over the world, with an estimated 65.9 million of hospitalizations among all ages and causing 2,377,697 deaths in 2016.[3] In 2017, the GDB study showed that the total deaths from lower respiratory tract infections had fallen by 36% between 2007 and 2017 in children younger than 5 years of age, but had risen by 34% in adults ages 70 years or older.[4]

In the US, the annual incidence of CAP has been estimated at 24.8 cases in 10,000 adults.[5] Pneumonia and influenza, when considered together, were the eighth leading cause of death (13.5 deaths in 100,000 population) and the leading infectious cause in the US in 2016.[6]

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