The global burden of diseases, injuries, and risk factors (GDB) study showed that lower respiratory tract infections affected over 336 million people all over the world, with an estimated 65.9 million of hospitalizations among all ages and causing 2,377,697 deaths in 2016.[3]GBD 2016 Lower Respiratory Infections Collaborators. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Infect Dis. 2018 Nov;18(11):1191-210.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202443
http://www.ncbi.nlm.nih.gov/pubmed/30243584?tool=bestpractice.com
In 2017, the GDB study showed that the total deaths from lower respiratory tract infections had fallen by 36% between 2007 and 2017 in children younger than 5 years of age, but had risen by 34% in adults ages 70 years or older.[4]GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 Nov 10;392(10159):1736-788.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6227606
http://www.ncbi.nlm.nih.gov/pubmed/30496103?tool=bestpractice.com
In the US, the annual incidence of CAP has been estimated at 24.8 cases in 10,000 adults.[5]Jain S, Self WH, Wunderink RG, et al. Community-acquired pneumonia requiring hospitalization among US adults. N Engl J Med. 2015 Jul 30;373(5):415-27.
http://www.nejm.org/doi/full/10.1056/NEJMoa1500245
http://www.ncbi.nlm.nih.gov/pubmed/26172429?tool=bestpractice.com
Pneumonia and influenza, when considered together, were the eighth leading cause of death (13.5 deaths in 100,000 population) and the leading infectious cause in the US in 2016.[6]Kochanek KD, Murphy SL, Xu J, et al. Deaths: final data for 2016. Natl Vital Stat Rep. 2018 Jul;67(5):1-76.
https://www.cdc.gov/nchs/hus
http://www.ncbi.nlm.nih.gov/pubmed/30248015?tool=bestpractice.com