Last reviewed:December 2019
Last updated:December  2019

Summary

Definition

History and exam

Key diagnostic factors

  • headache
  • palpitations
  • diaphoresis
  • hypertension
  • hypertensive retinopathy
  • pallor
  • impaired glucose tolerance/diabetes mellitus
  • family history of endocrine disorders
  • history of prior pheochromocytoma
  • tachyarrhythmias and myocardial infarction
  • panic attacks or a "sense of doom"

Other diagnostic factors

  • orthostatic hypotension
  • hypercalcemia
  • Cushing syndrome
  • diarrhea
  • fever
  • papilledema
  • abdominal masses
  • tremors

Risk factors

  • Multiple endocrine neoplasia (MEN) syndrome type 2A and B
  • Von Hippel-Lindau (VHL) disease
  • neurofibromatosis type 1 (NF1)
  • succinate dehydrogenase (SDH) subunit B, C, and D gene mutations

Diagnostic investigations

Treatment algorithm

Contributors

Bridget Sinnott

Associate Professor of Medicine

Medical College of Georgia

Augusta

GA

Disclosures

BS declares that she has no competing interests.

Dr Bridget Sinnott would like to gratefully acknowledge Dr Sidhbh Gallagher, a previous contributor to this topic. SG declares that she has no competing interests.

Peer reviewersVIEW ALL

Clinical Endocrinologist and Research Scientist

Department of Endocrinology, Diabetes, and Metabolism

Cleveland Clinic

Cleveland

OH

Disclosures

BAH declares that she has no competing interests.

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