Last reviewed: 8 Apr 2021
Last updated: 08 Apr 2021

Summary

Differentials

Common

  • Diabetes mellitus
  • Hypothyroidism
  • Vitamin B12 deficiency
  • Toxin/drug induced
  • Idiopathic polyneuropathy
  • Radiculopathy

Uncommon

  • Guillain-Barre syndrome
  • Cauda equina syndrome
  • Mononeuritis multiplex (vasculitic neuropathy)
  • Chronic inflammatory demyelinating polyradiculoneuropathy
  • Acromegaly
  • HIV
  • Hepatitis C
  • Diphtheria
  • Leprosy
  • Sjögren syndrome
  • Systemic lupus erythematosus
  • Monoclonal gammopathy
  • Amyloidosis
  • Chronic renal failure
  • Paraneoplastic polyneuropathy
  • Thiamine deficiency
  • Pyridoxine (vitamin B6) deficiency or toxicity
  • Lyme disease
  • Vitamin E deficiency
  • Copper deficiency
  • Charcot-Marie-Tooth neuropathy
  • Acute intermittent porphyria
  • Adrenomyeloneuropathy
  • Mitochondrial neuropathy
  • Fabry disease
  • Refsum disease
  • Tangier disease
  • Critical illness polyneuropathy and myopathy
  • Celiac disease and gluten sensitivity
  • Plexopathy

Contributors

Assistant Professor

Department of Neurology

Tulane University

New Orleans

LA

Disclosures

MHL declares that he has no competing interests.

Richard M Paddison Professor

Chair, Department of Neurology 

Editor-in-Chief for Journal of the Neurological Sciences

Louisiana State University Health Sciences Center School of Medicine

New Orleans

LA

Disclosures

JDE is the Editor-in-Chief for the Journal of the Neurological Sciences. JDE is on the speakers' bureau for Grifols and Takeda. JDE is an author of articles cited in this topic.

Dr John D England and Dr Maxwell H Levy would like to gratefully acknowledge Dr Jeffrey W. Ralph, the previous contributor to this topic.

Disclosures

JWR declares that he has no competing interests.

Peer reviewersVIEW ALL

Professor

Neurology and Neurological Sciences

Stanford University

Stanford

CA

Disclosures

YS is an author of a reference cited in this topic.

Consultant Neurologist

Chief of Service

Neurosciences/Head and Neck Directorate

Imperial Healthcare Trust

Charing Cross Hospital

London

UK

Disclosures

RS declares that he has no competing interests.

Use of this content is subject to our disclaimer