Summary
Differentials
Common
- Diabetes mellitus
- Hypothyroidism
- Vitamin B12 deficiency
- Toxin/drug induced
- Idiopathic polyneuropathy
- Radiculopathy
Uncommon
- Guillain-Barre syndrome
- Cauda equina syndrome
- Mononeuritis multiplex (vasculitic neuropathy)
- Chronic inflammatory demyelinating polyradiculoneuropathy
- Acromegaly
- HIV
- Hepatitis C
- Diphtheria
- Leprosy
- Sjögren syndrome
- Systemic lupus erythematosus
- Monoclonal gammopathy
- Amyloidosis
- Chronic renal failure
- Paraneoplastic polyneuropathy
- Thiamine deficiency
- Pyridoxine (vitamin B6) deficiency or toxicity
- Lyme disease
- Vitamin E deficiency
- Copper deficiency
- Charcot-Marie-Tooth neuropathy
- Acute intermittent porphyria
- Adrenomyeloneuropathy
- Mitochondrial neuropathy
- Fabry disease
- Refsum disease
- Tangier disease
- Critical illness polyneuropathy and myopathy
- Celiac disease and gluten sensitivity
- Plexopathy
Contributors
Authors
Maxwell H Levy, MD
Assistant Professor
Department of Neurology
Tulane University
New Orleans
LA
Disclosures
MHL declares that he has no competing interests.
John D England, MD, FAAN
Richard M Paddison Professor
Chair, Department of Neurology
Editor-in-Chief for Journal of the Neurological Sciences
Louisiana State University Health Sciences Center School of Medicine
New Orleans
LA
Disclosures
JDE is the Editor-in-Chief for the Journal of the Neurological Sciences. JDE is on the speakers' bureau for Grifols and Takeda. JDE is an author of articles cited in this topic.
Acknowledgements
Dr John D England and Dr Maxwell H Levy would like to gratefully acknowledge Dr Jeffrey W. Ralph, the previous contributor to this topic.
Disclosures
JWR declares that he has no competing interests.
Peer reviewers
Yuen So, MD, PhD
Professor
Neurology and Neurological Sciences
Stanford University
Stanford
CA
Disclosures
YS is an author of a reference cited in this topic.
Raad Shakir, FRCP
Consultant Neurologist
Chief of Service
Neurosciences/Head and Neck Directorate
Imperial Healthcare Trust
Charing Cross Hospital
London
UK
Disclosures
RS declares that he has no competing interests.
References
Key articles
Van den Bergh PYK, van Doorn PA, Hadden RDM, et al. European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint Task Force-Second revision. J Peripher Nerv Syst. 2021 Sep;26(3):242-68.Full text Abstract
Pop-Busui R, Boulton AJ, Feldman EL, et al. Diabetic neuropathy: A position statement by the American Diabetes Association. Diabetes Care. 2017 Jan;40(1):136-54.Full text Abstract
England JD, Gronseth GS, Franklin G, et al; American Academy of Neurology. Practice Parameter: evaluation of distal symmetric polyneuropathy: role of laboratory and genetic testing (an evidence-based review). Report of the American Academy of Neurology, American Association of Neuromuscular and Electrodiagnostic Medicine, and American Academy of Physical Medicine and Rehabilitation. Neurology. 2009;72:185-92.Full text Abstract
Reference articles
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
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